透明质酸钠治疗膝骨性关节炎的临床效果及分析  

Study on the Effect of Sodium Hyaluronate Intra-articular Injection on the Treatment of Knee Osteoarthritis

作　　者：冯利刚[1] 

机构地区：[1]广东省深圳市中医院骨二科,广东深圳518000

出　　处：《中国医药指南》2011年第16期24-25,共2页Guide of China Medicine

摘　　要：目的通过观察透明质酸钠(SH)对膝骨性关节炎(OA)的临床疗效,探讨其作用机制。方法选择79例OA患者共95膝,根据病变程度分为轻、中、度3组(分别为41、29、25个患膝),予关节腔内注射SH,每周1次,连用5次,比较治疗前后临床症状,评定临床疗效,检测治疗前后关节液中IL-6、IL-8、TNF-α的变化。结果 OA的严重程度影响SH治疗效果,治疗后,3组患者临床症状均有不同程度的改善,IL-6、IL-8、TNF-α均有不同程度的降低。结论 SH对OA有确切的治疗作用,其机制可能与抑制炎性因子的表达及释放有关,同时,我们应提倡OA的早期治疗。Objective To investigate the clinical efficacy of sodium hyaluronate（SH） on knee osteoarthritis（OA）,and to study the mechanism.Methods 79 patients with a total of 95 patients with OA,according to,were divide into mild,moderate degree of the three groups（41,29,25）,to intra-articular injection of SH,once a week,for 5 weeks.Then we assessed clinical efficacy before and after treatment and tested the levels of fluid IL-6,IL-8,TNF-α.Results The severity of OA influensed the efficacy.After treatment,three groups of patients were improved,and IL-6,IL-8,TNF-α were significantly lower.Conclusion SH have the exact treatment on OA,whose mechanism may be related to inhibiting the expression and release of inflammatory factors,and we should promote the early treatment of OA.

关 键 词：透明质酸钠 膝骨性关节炎 

分 类 号：R684.3[医药卫生—骨科学]