人创伤性休克时白细胞表面LFA-1、Mac-1、CD18的表达  

Surface Expression of LFA-1, Mao-1 and CD18 on Leukocyte in Human Traumatic Shock

作　　者：王妍春[1] 赵克森[2] 

机构地区：[1]中国人民解放军广州军区广州总医院肾内科,邮政编码广州510010 [2]中国人民解放军第一军医大学病理生理学教研室

出　　处：《微循环学杂志》1999年第3期16-18,共3页Chinese Journal of Microcirculation

基　　金：国家自然科学基金!39270852

摘　　要：探讨人创伤性休克时白细胞表面ＬＦＡ－１、Ｍａc－１和ＣＤ１８表达变化。方法：间接免疫荧光标记法。结果：创伤性休克后多形核粒细胞（ＰＭＮｓ）表面ＬＦＡ－１、Ｍａｃ－１和ＣＤ１８表达呈下降趋势，但无显著意义（Ｐ＞０．０５）。单核细胞表面ＬＦＡ－１、Ｍａｃ－１和ＣＤ１８表达呈上升趋势，以ＣＤ１８为显著（Ｐ<０．０５）。结论：创伤后ＰＭＮｓ表面粘附分子表达量与它对内皮的粘附存在不一致性，而单核细胞粘附也似乎不仅仅依赖于粘附分子的表面受体表达增强。提示，单核细胞与ＰＭＮｓ在参与粘附反应时其表面ＣＤ１８表达量变化不一致，其功能调节是否一致尚待查明。To investigate the changes of LFA 1, Mao-- 1 and CD] 8 surfaceexpression on leukocyte in human traumatic shock. Method: Indirect immunofluorescence labeling method. Result: Down--regulation trend of surfaceLFA--1, Mao-- 1 and CD18 expression on PMNs was found, the difference wasunobvious(P<0. 05). However, the surface expression of LFA l, Mao-- 1 andCD18 on monocytes increased after trauma, especially CD18(P<0. 05 ). Conclusion: Leukocyte adhesion was inconsistent with the quantitative surface expression of adhesion molecule on leukocyte after trauma. And the changes ofCD18 surface expression on monocytes were inconsistent with that on PMNswhen they take part in adhesion.

关 键 词：创伤性休克 白细胞 粘附分子 整合蛋白 

分 类 号：R605.971[医药卫生—急诊医学]