高胆固醇血症大鼠血液流变性及脂质过氧化的研究  

Study of Hemorheology and Lipid Peroxidation in Experimental Hypercholesterolemic White Rats

作　　者：许艳[1] 葛京平[2] 周卓[2] 马波[1] 朱翔[1] 陈丽娜[1] 高佩琦[1] 

机构地区：[1]哈尔滨医科大学生物物理教研室,邮政编码哈尔滨150086 [2]北京大学生命科学院

出　　处：《微循环学杂志》1999年第3期23-24,共2页Chinese Journal of Microcirculation

摘　　要：通过对实验性高胆固醇血症大鼠血液流变学及脂质过氧化的研究，结果表明：随着血浆胆固醇水平升高，全血粘度（ｂ）、血浆粘度（p）、红细胞刚性指数（ＩＲ）及聚集指数等较正常对照组明显升高，红细胞压积明显降低，同时血浆脂质过氧化水平显著增加。进一步从亚细胞分析研究，结果表明：荧光偏振度，膜脂区徽粘度，各项异性显著增高，膜流动性降低。Some indexes of hemorheology and lipid peroxidation were investigated inthe experimental hypercholesterolemic white rats. The result indicated accordingto the elevating of cholesterolemic b, up, IR, ect. significantly increased(PM0. 01), while hematocrit decreased. With more analysis, fluorescence polarization and membrane microviscosity was increased. It suggest the membrane fluidity was decreased.

关 键 词：高胆固醇血症 血液流变性 脂质过氧化 

分 类 号：R589.202[医药卫生—内分泌]