纳米载体提高难溶性药物口服生物利用度的研究进展  

Nanocarriers for enhancing the oral bioavailability of poorly soluble drugs:research advances

作　　者：何晓玮[1] 赵燕敏[1] 包强[1] 叶晓莉[1] 李范珠[1] 

机构地区：[1]浙江中医药大学药学院,杭州310053

出　　处：《国际药学研究杂志》2011年第3期212-215,共4页Journal of International Pharmaceutical Research

摘　　要：纳米载体是药剂学备受关注的研究领域,作为一类新型给药系统,它能显著提高难溶性药物的溶解度、生物利用度和稳定性,且具有明显的缓释作用,因此得到了广泛的应用。目前常用于提高难溶性药物口服生物利用度的纳米载体有纳米脂质体、固体脂质纳米粒、纳米胶束、和纳米结晶等,它们的粒径、表面性质及其释药环境等是影响纳米载体药物口服吸收的主要因素。本文对纳米载体提高难溶性药物口服生物利用度的研究进展作一综述。Nanocarriers are of concern in the pharmaceutics.In current years much attention has been focused on the formulation design in order to improve oral absorption of highly low aqueous soluble compounds.Nanocarriers,as a new type of drug delivery systems,are found a rapidly development as a formulation strategy as they may enhance the solubility and bioavailability of poorly soluble drugs,improve drug stability and control drug release.Currently,various nanocarriers were used to improve the oral bioavailability of insoluble drugs,including nanoliposomes,solid lipid nanoparticles,nanomicelles,nanocrystal and so on.The oral absorption of drugs is mainly influenced by their particle size,surface properties,and the release environment.In this article,we briefly review research advances in nanocarriers for enhancing the bioavailability of poorly soluble drugs.

关 键 词：纳米载体 难溶性药物 投药 口服 生物利用度 

分 类 号：R943[医药卫生—药剂学]