野罂粟生物碱单体心血管效应的构效关系  

RELATIONS BETWEEN STRUCTURE AND EFFECTS OF MONOMERS OF PAPAVER NUDICAULE ALKALOID ON CARDIOVESCULAR SYSTEM

作　　者：王瑞婷[1] 张海娟[1] 郝希俊[1] 申兴斌[1] 石艳华[1] 姜福义[1] 

机构地区：[1]承德医学院

出　　处：《承德医学院学报》1999年第3期208-212,共5页Journal of Chengde Medical University

摘　　要：目的：观察野罂粟总生物碱中八种生物碱单体心血管应的构效关系。方法：采用离体实验观察单体对ＫＣｌ所致兔胸主动脉环收缩的影响，并以Ｖｅｒ 作对照。结果：野罂粟碱（ｎｕｄｉｃａｕｌｉｎｅ，Ⅰ）、瑞芙热米定（ｒｅｆｒａｍ ｉｄｉｎｅ，Ⅱ）、黑龙辛甲醚（ａｍ ｕｒｅｎｓｉｎｉｎｅ，Ⅳ）、黑龙辛（ａｍ ｕｒｅｎｓｉｎｅ，Ⅴ）、野罂粟醇（ａｍ ｕｒｏｌｉｎｅ，Ⅵ）和七号生物碱（Ⅶ）均可使ＫＣｌ量－ 效曲线不平行右移，最大反应压低，其ＩＣ５０分别为０．２０，０．８０，０．１６，０．６０，０．６０，０．１６ｍ ｍ ｏｌ·Ｌ－ １。结论：野罂粟碱类（Ⅱ，Ⅳ，Ⅴ，Ⅶ）对经ＰＤＣ钙内流抑制效果较强，其中以Ⅱ作用最强；原阿朴菲类（Ⅵ，ⅧＡ。Objective:To study relations between the structure and effects of eight monmers of papver nudicaule alkaloids on cardiovescular.Methods:Isolated rabbit aortic rings were used to study the effects of eight monomers on their contraction induced by KCl.Results:Monomer Ⅰ,Ⅱ,Ⅵ,Ⅴ,ⅥandⅦshifted KCl dose response curves to right in unparallel fashion and decreased the maximal response.The IC 50 of them were 0.2,0.08,0.16,0.60,0.60,0.16mmol.L -1 ,respectively.Conclusion:The inhibitory effect of the isopapaver group to Ca 2+ influx through PDC is more intensive than that of proapromorphine group. Monomer Ⅱ is the most intensive of the isopapaver group.

关 键 词：野罂粟 生物碱 单体 钙通道 兔主动脉 

分 类 号：R971.2[医药卫生—药品]