早期微量喂养及补充益生菌对胃肠功能障碍危重早产儿的临床价值研究  

The Clinical Application Value of Endangered Preterm Infants Given Earlier Amounts of Micro Feedings and Adding Probiotics

作　　者：杨树杰[1] 易海英[1] 甘斌[1] 徐舒[1] 邓香兰[1] 万江[1] 

机构地区：[1]华中科技大学同济医学院附属孝感医院,湖北孝感432000

出　　处：《儿科药学杂志》2011年第3期21-24,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨早期微量喂养及益生菌的补充对胃肠功能障碍的危重早产儿临床应用价值。方法:2008年1月～2010年6月危重早产儿伴胃肠功能障碍92例,随机分三组,Ⅰ组(早期微量喂养及补充益生菌组)31例,Ⅱ组(早期微量喂养组)31例,Ⅲ组(非早期喂养组)30例。比较三组患儿生后1 d、7 d、14 d胃泌素、胃动素水平,临床监测三组患儿胃肠功能障碍持续时间、胎便排泄时间、协助排便时间、达足量喂养时间、静脉营养时间、恢复出生体重时间及合并症发生情况。结果:三组患儿生后7 d、14 d胃泌素及胃动素水平有不同程度升高,Ⅲ组与Ⅰ组、Ⅱ组之间差异有统计学意义(P<0.05)。胃肠功能障碍时间Ⅲ组与Ⅰ组、Ⅱ组相比差异有统计学意义(P<0.01)。三组患儿在胎便排泄完时间、协助排便时间、恢复出生体重时间及静脉营养时间方面,Ⅲ组与Ⅱ组、Ⅰ组相比差异有统计学意义(P<0.05)。达足量喂养时间Ⅰ组与另外两组比较差异有统计学意义(P<0.05)。三组患儿院内感染和高胆红素血症方面Ⅲ组与Ⅰ组比较差异有统计学意义(P<0.05);贫血、坏死性小肠结肠炎及呼吸暂停方面三组患儿之间比较差异无统计学意义(P>0.05)。结论:早期合理微量喂养及益生菌补充可以更好地促进危重早产儿胃肠功能障碍者胃泌素和胃动素的分泌,及时有效地控制胃肠功能障碍的发展,改善危重早产儿的胃肠道喂养和营养,减少合并症的发生。Objective：To explore the clinical application value of endangered preterm infants with gastrointestinal tract functional disturbance who were given earlier amounts of micro feedings and adding beneficial live bacterium.Methods： Ninety-two endangered preterm infants with gastrointestinal tract functional disturbance in our department from January 2008 to June 2010 were randomly divided into three groups（Early feedings and added the probiotic group,Early feedings group,No early feedings group）,then we determined the gastrin and motilin level in the first,seventh,and fourteenth day of the three groups.Meanwhile we monitored the time of the gastrointestinal tract functional disturbance,the meconium egesting,assisting egesting,reaching the sufficient feeding,intravenous nutrition,anastating birth weight and any complication.Results： The level of the serum gastrin and motilin raised after the seventh and fourteenth day,the differences between the third and the first with the second group were statistically significant（P0.05）.The differences between the third and the first with the second group were statistically significant in the time of the gastrointestinal tract functional disturbance（P0.01）.Comparing the time of the meconium egesting,assisting egesting,anastating birth weight and intravenous nutrition in the three groups we found that the differences between the third and the first with the second group were statistically significant（P0.05）.Compared the first group with the other two groups,the differences that they reached with sufficient feeding were statistically significant（P0.05）.Comparing the incidence rate of the hospital onset of infection and the hyperbilirubinemia in the duration of hospital stay between the three groups we found that the differences between the third group and the first group were statistically significant（P0.05）.Meanwhile comparing the incidence rate of the anemia,the necrotizing enterocolitis and the breathing holding we also found the differences between

关 键 词：益生菌 婴儿 早产 胃肠功能 喂养 

分 类 号：R725.7[医药卫生—儿科]