深圳儿童医院2010年常见病原菌分布及耐药性调查  

Antibiotic-resistance and Distribution of Nosocomial Infection Pathogens among Children Patients in Shenzhen Children's Hospital

作　　者：胡瑛[1] 文飞球[1] 钟春梅[1] 王红梅[1] 

机构地区：[1]广东省深圳市儿童医院,广东深圳518026

出　　处：《儿科药学杂志》2011年第3期43-46,共4页Journal of Pediatric Pharmacy

摘　　要：目的:了解医院常见病原菌及其耐药情况,为临床用药提供参考。方法:对深圳市儿童医院2010年1月～12月住院患儿检出的病原菌分布及耐药情况进行回顾性分析。结果:共检出常见病原菌3 629株,其中革兰阴性(G-)菌2 493株,占68.7%,革兰阳性(G+)菌1 136株,占31.3%。G-杆菌以肺炎克雷伯菌(22.7%)、大肠埃希菌(20.4%)、鲍曼不动杆菌(10.7%)等为主,肺炎克雷伯菌和大肠埃希菌产ESBLs率分别是41.3%和51.7%;G+球菌中MRSA检出率为15.5%。G-杆菌对碳青霉烯类及酶抑制剂表现出较高的药物敏感性,对氨基青霉素类耐药性高;G+菌未检出碳青霉烯类、安沙霉素类、磷霉素类、糖肽类及链阳霉素类药物的耐药菌株,对青霉素G耐药率高达93.5%。结论:本地区儿童感染疾病以下呼吸道感染为主,病原菌以肠杆菌科细菌及葡萄球菌为主,对碳青霉烯类(亚胺培南)和糖肽类抗生素(万古霉素)仍保持高度的药物敏感性。Objective：To understand the main pathogens of nosocomial infection and analyze its distribution as well as its drug resistance,then to find an effective way to deal with such pathogens.Methods： Made a retrospective investigation on the clinical data of hospitalized patients who stayed in Shenzhen Children＇s Hospital during January to December 2010.Results： It appeared 3,629 cases,among which there were 2,493 Gram-negative strains（took up 68.7%）,while Gram-positive were 1,136 strains（took up 31.3%）.The main pathogens were Klebsiella pneumoniae（22.7%）,Escherichia coli（20.4%）,and Acinetobacter baumanii（10.7%） among gram negative bacteria.The ESBLs-producing rates of Escherichia coli and Klebsiella pneumoniae were 51.7% and 41.3% while MRSA in gram positive coccus was 15.5%.Gram-negative pathogens showed high rates of drug-sensitivity on carbapenem and enzyme inhibitors,and gram-positive pathogens showed 93.5% drug resistance to penicillin.No resistant strains to carbapenem,rifampin,ansamycins,fosfomycin and glycopeptides were detected.Conclusions： The main infection in our hospital was lower respiratory tract ones,carbapenem and vancomycin remain highly active against Enterobacteriaceae and Staphylococci which were the main pathogens in our hospital.

关 键 词：院内感染 病原菌 耐药性 

分 类 号：R969.3[医药卫生—药理学]