青海省实施小学生乙型肝炎疫苗接种和健康教育项目血清学效果评价  

Evaluation of the Serological Effect on the Implementation HepB Immunization and Health Education Project for the Primary Students

作　　者：阿克忠[1] 马小军[1] 张永基 张守荣[1] 巴文生[1] 李连伟[1] 

机构地区：[1]青海省疾病预防控制中心,西宁810007

出　　处：《中国疫苗和免疫》2011年第3期220-221,226,共3页Chinese Journal of Vaccines and Immunization

基　　金：中国肝炎防治基金会支持项目

摘　　要：目的通过青海省小学生乙型肝炎(乙肝)疫苗(Hepatitis B Vaccine,HepB)接种和健康教育项目,提高全省儿童HepB覆盖率,为制定HepB免疫策略提供依据。方法对儿童进行免疫前、后血清抗体检测,了解HepB免疫学效果。结果 333337名儿童接种了10μg(微克)重组HepB(中国仓鼠卵巢细胞),全省报告全程接种率97.51%,调查接种率99.02%,免疫后抗乙肝病毒表面抗原抗体(Antibody to Hepatitis B Virus Surface Antigin,Anti-HBs)阳性率94.94%。385名免疫前Anti-HBs阴性儿童,免疫后Anti-HBs阳转率95.32%。免疫前、后Anti-HBs几何平均浓度差异有统计学意义(F=217.23,P<0.001)。结论青海省实施小学生HepB接种和健康教育项目加速了预防控制乙肝步伐,为预防和控制乙肝起到了推动作用。Objectives To improve hepatitis B vaccine（HepB）coverage of children in Qinghai province, and to provides basis for developing HepB immunization strategies through implementing the project of HepB immunization and health education. Methods The serum antibody before and after immunization were tested respectively. Results 333,337 children had vaccinated 10μg Recombinant HepB（China Hamster Ovary cell, CHO）, the reported full course coverage rate was 97.51%, survey coverage rate was 99.02%. Antibody to hepatitis B virus surface antigen（Anti-HBs） positive rate was 94.94% after immunization, 385 children whose Anti-HBs were negative before immunization, Anti-HBs positive rate was 95.32% after immunization. The difference of anti-HBs was statistically significant（F=217.23, P0.001）in Geometric Mean Concentration（GMC）before and after immunization. Conclusions The project had obvious effects for hepatitis B prevention and control.

关 键 词：乙型肝炎疫苗 血清学效果 健康教育 评价 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]