血浆结合珠蛋白与冠心病相关性研究  

Correlation of serum haptoglobin with coronary heart disease

作　　者：张宇[1] 邱春光[1] 韩战营[1] 卢文杰[1] 陈晓杰[1] 

机构地区：[1]郑州大学第一附属医院心血管内科,450052

出　　处：《中国实用医刊》2011年第12期6-8,共3页Chinese Journal of Practical Medicine

摘　　要：目的通过对不同类型冠心病患者血浆中结合珠蛋白（haptoglobin，Hp）水平比较，探讨其与冠状动脉粥样硬化病变的关系，并评价血浆Hp水平在冠心病患者危险分层中的作用。方法选取186例心内科住院患者根据临床症状、体征、心电图及冠状动脉造影将患者分为：稳定性心绞痛（SAP）组，48例；不稳定性心绞痛（UAP）组，90例；急性心肌梗死（AMI）组，48例；同时选取健康对照组，40例。应用酶联免疫吸附试验（ELISA）测定血浆Hp水平，同时检测血清中的总胆固醇（Tc）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）的水平，超敏C反应蛋白（hs—CRP），比较不同组患者之间血浆Hp水平的差异。结果SAP组、UAP组、AMI组患者血浆Hp浓度明显高于对照组。血浆Hp平均浓度在对照组、SAP组、UAP组、AMI组间两两比较差异均有统计学意义（P〈0．05）。结论冠心病患者血浆Hp浓度比正常人血清浓度明显升高，血浆Hp可以作为冠心病预测及诊断因子。Objective To explore the relationship between serum haptoglobin （Hp） and coronary heart disease and evaluate the role of serum Hp level in coronary heart disease risk stratification. Methods One hundred and eightysix patients were selected according to the clinical features and resuits of the ECG and CAG, the patients were divided into 3 groups ： stable angina group, 48 cases ; unsta- ble angina group, 90 cases; acute myocardial infarction group, 48 cases; select 40 cases as heathy con- trol groups. Testing the Hp levels of the patients＇ serum samples by enzyme - linked immunosorbent as- say （ELISA） , at the same time testing the TC, TG, LDL - C, HDL - C levels. Results Hp levels of stable angina patients, unstable angina patients and acute myocardial infarction patients were obviously higher than that of healthy persons. Based on result of completely randomized variance analysis, Hp levels was increased successively from healthy persons to stable angina patients, unstable angina patients and acute myocardial infarction patients, showing significant difference. It was positively correlated with coro- nary condition. Conclusions Hp levels of patients with coronary heart disease is higher than that of healthy person. The serum Hp can be predicative and diagnostic factor of coronary heart disease.

关 键 词：结合珠蛋白 超敏C反应蛋白 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]