伊班磷酸钠联合钙剂和维生素D治疗炎症性肠病性骨质疏松的疗效观察  

Observations of the Effects of Ibandronate Injections with Calcium and Vitamin D in Treatment of Osteoporosis which Inflammatory Bowel Disease(IBD)

作　　者：张瑜[1] 金建军[1] 赵双琴[1] 张世同[1] 张英剑[1] 白艳丽[1] 郑玉峰[1] 

机构地区：[1]河南科技大学第一附属医院消化科,河南洛阳471003

出　　处：《中国医药指南》2011年第17期181-182,共2页Guide of China Medicine

摘　　要：目的探讨伊班磷酸钠联合钙剂和维生素D治疗炎症性肠病性骨质疏松的疗效和安全性。方法来自河南科技大学第一附属医院经定量CT(QCT)诊断为炎症性肠病骨质疏松和骨量减少的49例患者,给予钙剂和维生素D治疗,另外静脉滴注伊班磷酸钠1mg,每3个月1次,在治疗前、后6个月和1年进行QCT扫描。结果治疗6个月、1年后腰椎骨密度较治疗前有明显增加(P<0.05、P<0.01)。结论静脉滴注伊班磷酸钠联合口服钙剂和维生素D治疗炎症性肠病引起的骨质疏松和骨量减少是一项耐受性较好的方案。Objective To investigate the efficacy and safety of ibandronate injections with calcium and vitamin D in treatment of osteoporosis which inflammatory bowel disease（IBD） induced.Methods 49 patients diagnosed of IBD induced osteoporosis and osteopenia by quantitative CT（QCT） were included in the study.Calcium and vitamin D were administered to patients.In addition,1mg of ibandronate was administered intravenously every 3 months.QCT was performed prior to treatment,after 6 months and after 1 year.Results BMD at lumbar were increased after 6 months and after 1 year（P〈0.05,P〈0.01）.Conclusion Ibandronate injections with calcium and vitamin D is a well tolerated strategy for treating IBD associated osteopenia and osteoporosis.

关 键 词：伊班磷酸钠 炎症性肠病 骨质疏松 

分 类 号：R591.1[医药卫生—内科学]