吸入麻醉药作用的新靶点--双孔钾通道  

New targets of inhalational anesthetics-two-pore-domain potassium channels

作　　者：李世勇[1] 罗爱林[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科,武汉430030

出　　处：《国际麻醉学与复苏杂志》2011年第3期320-322,327,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金资助项目（30772086）

摘　　要：背景 尽管吸人麻醉药在临床上应用已久，但其作用的分子机制不是很清楚。双孔钾离子通道（two pore potassium channels，K2P）足新发现的钾通道超家族的一员，它被认为是吸入麻醉药敏感性钾通道的分子基础。目的 综合K2P通道相关文献，阐述K2P通道在吸入麻醉药作用机制中的研究进展。内容 简要概述K2P通道结构、功能及分类，重点介绍吸人麻醉药敏感性钾通道作为吸人麻醉药作用靶点的实验室依据。趋向 通过进一步阐释K2P通道在吸入麻醉药伞身麻醉中的作川，有且力于阐明吸人麻醉药分子作用机制和开发作用于K2P的新麻醉药物。，Background The molecular mechanism of inhalational anesthetics is not fully understood,though it had beenadministred clinically for a long time. Two-pore-domain potassium channels（K2P channels）,a new member of K channels supeffamily,are deemed as molecular basis of inhalatinnal anesthetics-sensitive K＋channels.Objective To elucidate the advance in inhalational anesthetics mechanism of K2P channels via summarizing the documents related to K2P channels.Content This review concisely outlines the structule,function and classification of K2P channels and thoroughly presents the experimental evidence that jnhalational anesthetics-sensitive K ＋ channels are the target of inhalational anestheties.Trend To further verify the role of K2Pchannels in general anesthesia of inhalational anesthetics would be helpful to expound the molecular mechanism of inhalational anesthetics and develop new anesthetic drugs acting on K2P channels.

关 键 词：麻醉药 吸人 双孔钾通道 作用靶点 

分 类 号：R614[医药卫生—麻醉学]