大头陈挥发油的化学成分分析及其抗菌活性  

Chemical Constituents and Anti-bacterial Activity of Essential Oil form Adenosma indianum

作　　者：黄燕[1] 吴怀恩[1] 韦志英[1] 肖艳芬[1] 余晓玲[1] 

机构地区：[1]广西中医学院,南宁530001

出　　处：《中国实验方剂学杂志》2011年第12期79-82,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究壮药大头陈挥发油的主要化学成分及其抗菌活性。方法:采用水蒸气蒸馏法提取大头陈挥发油,通过GC-MS技术对其进行分析,面积归一化法测定计算各成分的质量分数;并采用连续稀释法对大头陈挥发油进行最低抑菌浓度(MIC)、最低杀菌浓度(MBC)的实验研究。结果:水蒸气蒸馏法提取的挥发油共鉴定出57种成分,占挥发油总成分的92.19%,其中主要含雪松醇(26.02%)、柠檬烯(13.46%)。大头陈挥发油在体外对金黄色葡萄球菌、金黄色葡萄球菌耐药株等均有一定的抗菌作用。结论:实验结果可为大头陈的药效物质研究提供科学依据。Objective：To study the chemical constituents and antibacterial activity of essential oil from Adenosma indianum Method：The essential oils were extracted from Adenosma indianum by steam distillation.The amount of the constituents from the essential oil was determined by normalization method,and the constituents separated were identified by GC-MS.The antibacterial tests of MIC and MBC for the essential oil were studied by using tubes serial dilution method.Result：There were 57 constituents from Adenosma indianum by SD that composed of about 92.19% of the total essential oil were separated and identified.It mainly contained cedrol（26.02%） and limonene（13.46%）.The essential oil showed some antibacterial effect to staphylococcus aureus and drug-resistant strains of staphylococcus aureus,etc.Conclusion：It can provide scientific basis for the effective substances of A.indianum.

关 键 词：大头陈 挥发油 化学成分 抗菌活性 

分 类 号：R284.1[医药卫生—中药学]