妇炎康灌肠剂中芍药苷在家兔体内药代动力学  

Pharmacokinetics of Fuyankang Enema in Rabbits

作　　者：陈小新[1,2] 原素 龙超峰[2] 赖小平[1] 

机构地区：[1]广州中医药大学,广州510405 [2]广东华南药业集团有限公司,广东东莞523325

出　　处：《中国实验方剂学杂志》2011年第12期106-109,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:测定妇炎康灌肠剂有效成分芍药苷的药动学参数,为临床合理用药提供科学依据。方法:分别单剂量ig与灌肠给予家兔妇炎康灌肠剂,用HPLC测定血浆中芍药苷的浓度,用3p97程序拟合药物浓度-时间曲线,计算药动学参数。结果:ig给药后,血浆中未能检出芍药苷;直肠给药后,芍药苷在家兔体内过程符合一室开放模型,药动学参数为:ka为3.190 9 h-1,ke为0.943 8 h-1,t1/2(ka)为0.217 2 h,t1/2(ke)为0.734 4 h,Tmax为0.542 1 h,Cmax为0.542 1 mg·L-1,AUC0-4 h为9.260 2 mg·L-1 h-1。结论:与ig给药比较,妇炎康灌肠剂经直肠给药后其主要有效成分在家兔体内吸收更加迅速、完全。Objective：To investigate pharmacokinetics for paeoniflorin of Fuyankang enema in rabbits and provide scientific basis for clinical application.Method：The pharmacokinetic study of paeoniflorin after rectal administration and administration by gavage with single dose was investigated by using above HPLC method respectively,the pharmacokinetics parameters was calculated with 3p97 programs.Result：Administration by gavage,the paeoniflorin wasn＇t detected in the rabbit plasma by HPLC method established and the pharmacokinetic parameter of wasn＇t obtained.After rectal administration,the curve of paeoniflorin plasma concentration-time could be described by a one-compartment model,correlation pharmacokinetic parameter described as follows：ka was 3.190 9 h,ke was 0.943 8 h,t1/2（ka）was 0.217 2 h,t1/2（ke）was 0.734 4 h,Tmax was 0.542 1 h,Cmax was 5.239 7 mg·L-1,AUC0-4h was 9.260 2（mg·L-1）·h.Conclusion：The result indicated the absorption of paeoniflorin after rectal administration Fuyankang enema is much more superiority to administration by gavage.

关 键 词：妇炎康灌肠剂 芍药苷 药代动力学 

分 类 号：R285.5[医药卫生—中药学]