秦皮甲素大鼠肠吸收动力学  

Absorption Kinetics of Aesculin in Rats

作　　者：姜宇[1] 何群[1] 赵碧清[2] 何欣[3] 陈本超[1] 

机构地区：[1]湖南中医药大学中药现代化实验室,长沙410208 [2]湖南中医药大学药学院,长沙410208 [3]湖南中医药大学第一临床医学院,长沙410007

出　　处：《中国实验方剂学杂志》2011年第12期110-113,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨秦皮甲素在大鼠各肠段的吸收动力学特征。方法:以大鼠在体肠灌流模型从吸收部位、药物浓度考察秦皮甲素的肠吸收动力学情况。结果:秦皮甲素在大鼠各肠段吸收有差异,十二指肠、空肠、回肠中的Ka依次为0.185 0,0.186 5,0.065 7 min-1。结论:秦皮甲素在小肠吸收迅速完全,其吸收呈一级吸收动力学特征且吸收机制为被动转运,适于制成缓释给药系统。Objective：To investigate the absorption characteristics of aesculin in different intestinal segments of rats.Method：The study was performed by intestinal perfusion model in rats to observe the effect of absorption sites and concentrations on absorption kinetics of aesculin.Result：Aesculin had specific site in rat′s intestine,absorption rate constants were 0.185 0,0.186 5,0.065 7 min-1 in duodenum,jejunum and ileum respectively.Conclusion：Aesculin was rapidly and completely absorbed in whole segments of intestine.The behaviors conformed to passive-transport mechanism and first-order kinetics.All the above indicated that aesculin could be formulated to a sustained-release drug delivery system.

关 键 词：秦皮甲素 在体肠灌流 吸收动力学 

分 类 号：R285.5[医药卫生—中药学]