关于微透析法与血药浓度法的异同及其药动学数据特殊处理的探索与思考  

Exploration and Consideration about Differences and Similarities between Microdialysis Method and Blood Concentration Method and Pharmacokinetics Data Processing of Microdialysis Method

作　　者：张英丰[1] 吴阳[1] 汪小根[2] 周莉玲[1] 

机构地区：[1]广州中医药大学,广州510006 [2]广东食品药品职业学院,广州510520

出　　处：《中国实验方剂学杂志》2011年第12期276-278,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30701097;30672669;30873443);中国博士后基金项目(20070420509);广东省自然科学基金项目(9151052005000003)

摘　　要：从采样方式、采样原理、适用性、发展趋势、样品浓度与机体整体浓度的关联性角度比较微透析采样技术与经典药动学采样技术的异同,探讨微透析技术进行药动学研究的适用性,根据采样对象性质,深入思考其样品数据处理的特殊性,提出并总结关于微透析样品数据的校正方法以提升微透析技术进行药动学研究的稳健性及结果可靠性。The differences between classical pharmacokinetic sampling methods and microdialysis sampling technology was compared to investigate the applicability of pharmacokinetic study and the sample data processing particularity by using microdialysis technology from the sampling model,sampling principle,applicability,development trends and the relevance between sample concentration and body concentration.The data processing specificity of microdialysis samples were deeply thought according the study object characteristics.The microdialysis samples data correction method was summaried on this basis to improve the pharmacokinetic study results robustness and reliability by using microdialysis method.

关 键 词：微透析技术 经典药动学采样手段 异同 数据处理 

分 类 号：R284.1[医药卫生—中药学]