转化生长因子β_1基因-509 C/T及T细胞受体Cα基因-575 A/G对微型多血管炎肾损害治疗的影响  

Effects of polymorphisms of transforming growth factor β_1-509 C/T and T cell receptor Cα-575A/G on treatment of renal damage in micro-polyangiitis

作　　者：薛超[1] 卜昆鹏[1] 廖蕴华[1] 

机构地区：[1]广西医科大学第一附属医院肾内科,南宁530021

出　　处：《中国临床药理学杂志》2011年第6期403-406,共4页The Chinese Journal of Clinical Pharmacology

基　　金：广西医科大学校博士启动基金资助项目(308019);广西科学基金资助项目(桂科青0728060);广西卫生厅自筹基金资助项目(z200788)

摘　　要：目的研究转化生长因子β1(tgfβ1)基因-509 C/T和T细胞受体α链稳定链(Tcrcα)基因-575 A/G对微型多血管炎性肾损害的药物治疗的遗传学影响。方法患者均完成了一个疗程的糖皮质激素加环磷酰胺治疗方案。PCR-RFLP法鉴定基因型:tgfβ1-509 C/T表现为CC、TT、CT;Tcrcα-575A/G表现为AA、GG、AG,对比不同基因型的患者完成疗程后肾损害指标:尿蛋白程度、血尿素氮水平和血肌酐水平。结果 44例已知tgfβ1-509C/T 3种基因型患者,经治疗后,肾损害指标差异均无统计学意义(P>0.05);47例已知Tcrcα-575A/G 3种基因型的患者,经治疗后,肾损害指标差异均无统计学意义(P>0.05)。结论 tgfβ1-509 C/T、Tcrcα-575A/G可能对糖皮质激素加环磷酰胺治疗微型多血管炎性肾损害无个体遗传学效应。Objective To investigate possibly genetic influence of transforming growth factor β1（tgf β1） gene-509 C/T polymorphism and T cell receptor gene constant chain（Tcrc α）-575 A/G polymorphism on renal damage treatment in micro-polyangiitis.Methods Micro-polyangiitis patients with renal involved completed a course of steroid and cyclophosphamide treatment,genotypes were identified by PCR-RFLP.The renal impairment data（urine protein level,blood urea nitrogen level and serum creatinine level）from the patients of different genotypes were compared after completed their treatment plan.Results Forty-four patients with known tgf β1-509C/T genotype patients after treatment were checked,no statistically difference in either of renal impairment data（P0.05）.Forty-seven patients with known Tcrc α-575A/G genotypes,also with fulfilled treatment,no significantly differences in the renal impairment data too（P0.05）.Conclusion To glucocorticoid and cyclophosphamide treatment on micro-polyangiitis renal damage,however,tgf β1-509 C/T or Tcrc α-575A/G might have no genetic contribution to it.

关 键 词：基因 单核苷酸多态性 微型多血管炎 糖皮质激素 环磷酰胺 

分 类 号：R977.1[医药卫生—药品] R968[医药卫生—药学]