六茜素稳定性影响因素研究  

Study on the influence factors of pyroline's stability

作　　者：王学红[1] 郭文柱[1] 刘宇[1] 郝宝成[1] 郑红星[1] 梁剑平[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所甘肃省新兽药工程重点实验室中国农业科学院新兽药工程重点开放实验室,甘肃兰州730050

出　　处：《中兽医医药杂志》2011年第3期51-53,共3页Journal of Traditional Chinese Veterinary Medicine

基　　金：国家"十一五"科技支撑项目(2006BAD04A05-05)

摘　　要：目的:探讨六茜素的固有稳定性、了解影响其稳定性的因素及可能的降解途径与分解产物,为制剂生产工艺、包装、贮存条件提供科学依据。方法:分别通过高温试验、高湿度试验、强光照射试验等,考察六茜素制剂的稳定性。结果:六茜素在强光照射和高温条件下稳定,湿度和水分对六茜素的稳定性影响较大。结论:六茜素应密封贮存,使用时宜现配现用。Objective： To evaluate the inherent stability of pyroline, discuss the influence factors of its stability, possible degradation pathways and the decomposition products, so as to provide a scientific basis for the production process, packaging, storage conditions of the preparation. Methods： The test of high temperature, high humidity and highlight irradiation was carried out, respectively. Results： Pyroline was stable in bright light and high temperature, but instable in humid and aqueous solution. Conclusion： Pyroline should be sealed storage, and the existing service should be used.

关 键 词：六茜素 影响因素试验 稳定性 

分 类 号：S859.7[农业科学—临床兽医学]