手性选择体的固定量对固定相手性分离的影响  

The Influence of Selector Loading on the Enantioseparation of Chiral Stationary Phase

作　　者：刘学威[1] 魏文娟[1] 陈伟[1,2] 柏正武[1,2] 

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430073 [2]武汉工程大学绿色化工过程教育部重点实验室,湖北武汉430073

出　　处：《分析科学学报》2011年第3期302-306,共5页Journal of Analytical Science

基　　金：国家自然科学基金(No.20675061;50973086);湖北省教育厅重大项目(No.Z20081501)

摘　　要：为研究手性选择体的固定量对固定相对映体分离能力的影响,将L-(-)-二苯甲酰酒石酸与苯甲醇反应,制备出单苄酯,再将此单苄酯的另一羧基转化为酰氯,得到手性选择体,将此选择体固定在氨丙基硅胶上,制备出选择体固定量较高的固定相,比较了此固定相与前期工作中选择体相同但选择体固定量较低的固定相在手性分离能力方面的差异,此外讨论了温度对对映体分离的影响。In order to investigate the influence of selector loading on the enantioseparation ability of chiral stationary phase,L-（-）-dibenzoyl tartaric acid was mono-esterfied with benzyl alcohol and chloride in sequence to afford a chiral selector,which was then immobilized on aminated silica gel to give a chiral stationary phase with higher selector loading.The comparison in chiral recognition between this chiral stationary phase and the one with lower selector loading prepared previously was made.In addition,the influence of temperature on the enantioseparation was also discussed.

关 键 词：手性选择体 固定量 L-(-)-二苯甲酰酒石酸 对映体分离 高效液相色谱 

分 类 号：O657.72[理学—分析化学]