含药聚氧化乙烯共聚水凝胶膜的制备及其性能研究  

PREPARATION OF REINFORCED POLY(ETHYLENE OXIDE) BLEND HYDROGEL FILMS CONTAINING A DRUG AND ASSESSMENT OF THEIR PROPERTIES

作　　者：杨占山[1] 朱南康[1] 杨淑琴[1] 

机构地区：[1]苏州医学院,苏州215007

出　　处：《辐射研究与辐射工艺学报》1999年第4期214-218,共5页Journal of Radiation Research and Radiation Processing

基　　金：中国核工业科学基金

摘　　要：应用冻融循环和辐射交联技术，制备了含有醋酸氨苄磺胺的增强的聚氧化乙烯共聚水凝胶膜，并对其理化性能和药物释放进行了研究。实验结果显示，与未经冻融循环处理的聚氧化乙烯共聚水凝胶膜比较，增强的聚氧化乙烯共聚水凝胶膜的抗张强度明显增加（p＜0．01），凝胶分数和断裂伸长率亦稍有增加，表明冻融循环处理可明显地改善该膜的机械性能，使该膜作为伤口敷料具有理想的柔韧性、交联度和伸缩性。溶胀度研究显示，该水凝胶膜的平衡水含量明显降低（p＜0．01），表明该膜在冷冻时发生了有意义的结构重组，结构的密度增加导致机械强度的增加。应用40kGy的电子束照射形成的聚氧化乙烯共聚水凝胶膜的抗张强度最高。在冻融前掺入醋酸氨苄磺胺的聚氧化乙烯共聚水凝胶膜用于释放研究，其药物释放持续7d，释放曲线符合药物的扩散性模型。Reinforced poly(ethylene oxide) blend hydrogel films containing mafenide acetate were prepared by using two freezing-thawing cycles and the irradiation crosslinking technique, and their properties and the drug release were assessed. The results showed that the tensile strength of the reinforced PEO blend hydrogel films increased significantly (p <0.01), the gel fraction and the elongation at break of the films increased slightly as compared with those formed by the irradiation without the freezing-thawing treatment, indicating that the mechanical properties of the PEO blend hydrogel films can be improved by the freezing-thawing cycles. The reinforced films possessed an ideal flexibility, crosslinking density and elasticity as wound dressings. Swelling studies showed that the equilibrium water content of the hydrogel films expressed in the degree of swelling decreased significantly (p <0.01), suggesting that a significant structural rearrangement of the films occurred during the freezing process. The structural densification resulted in the increase of the mechanical strength of the hydrogel films. The hydrogels formed by the irradiation at doses of 40 kGy were comparatively strollger. Release studies were run on the reinforced hydrogels with mafenide acetate which was incorporated before the freezing-thawing treatment. Release was followed over seven days. The drug transport was controlled by a regular diffusion model.

关 键 词：聚氧化乙烯 水凝胶膜 冻融处理 辐射交联 

分 类 号：R982[医药卫生—药品]