胃癌肝胃不和证的前瞻性队列研究及相关因素的Logistic回归分析  

Discussion on Hepatogstric Disagreement Card by Logistic Regression Analysis of Relative Factor and Cohort Study

作　　者：王克穷[1] 马娟[1] 于明洋[1] 毛照海 马永录 

机构地区：[1]陕西中医学院,陕西咸阳712000 [2]武威市中医医院,甘肃武威733000 [3]甘肃省酒泉地区医院,甘肃酒泉735000

出　　处：《辽宁中医杂志》2011年第6期1087-1089,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科研基金课题(30873471)

摘　　要：目的:探索胃癌在手术、化疗前后肝胃不和证与临床因素的相互关系,以期指导临床。方法:通过对466人1097次胃癌手术、化疗前后患者的前瞻性队列调查,以胃癌肝胃不和证为因变量,以临床因素为自变量进行logistic回归分析。结果:肝胃不和证发病率为21.79%;其中,术前、术后(或术后化疗前)和术后化疗后分别为31.82%、20.31%和16.16%。从logistic回归分析来看,术前呈正相关者依次是:瘤体直径、卡氏评分;呈负相关:淋巴结转移。术后化疗前呈正相关者依次是:瘤体直径、外科切缘、化疗间歇期服用中药、TNM分期;呈负相关:化疗次数。术后化疗后呈正相关者依次是:瘤体直径、外科切缘和TNM分期;呈负相关:组织学分级、化疗间歇期服用中药。结论:治疗手段不同、时间不同,胃癌肝胃不和证的发病率不同,临床影响因素也不同。Objective：To stadey the relationship of the clinical factors and the hepatogstric disagreement card on Gastric carcinoma of Pre-and Post Surgical and Chemotherapy,and guide the clinical practice.Methods：A prospective cohort study of pre-and post results of 1097 gastric carcinoma operations and chemotherapies of 466 caces was carried out,taking the hepatogstric disagreement card on gastric carcinoma as the clinical factors as the independent variables.Results：The incidence of hepatogstric disagreement card on Gastric carcinoma was 21.79%.The incidence rate of preoperative,postoperative ﹠ before chemotherapy were31.82%,20.31%,16.16%.With the Logistic regression analysis,the positive correlations of postoperative gastric carcinoma were tumor diameter,Karnofsky Score of performance status,the negative correlations of its was Lymph node metastasis.The positive correlation of post operative ﹠ before chemotherapy were tumor diameter,surgical cutting edge,the patients took the traditional Chinese Medicine with postoperative and TNM staging,the negative correlations of its was the namber of chemotherapy.The positive correlation of post operative ﹠after chemotherapy were tumor diameter,surgical cutting edge and TNM staging,the negative correlations of its was histological grading the patients took the traditional Chinese Medicine with postoperative.Conclusion：Effect of different therapeutic approaches and time could play an important role in different incidence rate of hepatogstric disagreement card on gastric carcinoma and different clinical factors.

关 键 词：胃癌 肝胃不和证 临床因素 队列研究 回归分析 

分 类 号：R2-03[医药卫生—中医学]