弥漫性肺间质疾病中医证素分布与组合规律研究  

Study on distribution and combination regularity of TCM syndrome factors of diffuse interstitial lung disease

作　　者：李素云[1] 李亚[1,2] 邓丽[3] 赵栋梁[3] 王明航[1] 王海峰[1] 李建生[1,3] 

机构地区：[1]河南中医学院第一附属医院呼吸病研究室,郑州450000 [2]北京中医药大学,北京100029 [3]河南中医学院老年医学研究所,郑州450008

出　　处：《中华中医药杂志》2011年第6期1289-1292,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省高校新世纪优秀人才支持计划课题资助项目(No.2006HANCET-05)~~

摘　　要：目的:通过对住院病例的回顾性调查,探讨弥漫性肺间质疾病中医证素分布与组合规律,指导中医辨证。方法:根据对弥漫性肺间质疾病中医临床研究的流行病学调查要求,制订《弥漫性肺间质疾病临床调查表》,并建立证素证候研究数据库,采用SPSS 13.0统计软件进行统计描述。结果:12个病性证素中,痰(饮)和出现频率最高(80.76%),其次为气虚、热、瘀血、阴虚、湿(浊)等,频率分别为50.95%、41.44%、33.62%、21.56%、19.24%等;靶点主要位于肺,其频率为93.23%,其次为在肾和脾(36.79%和7.61%)等。在证素不同的组合中,单一证素构成的证候主要有血瘀证(1.57%)。靶点在肺、肾、脾,表现为肺气虚证、肾气虚证、脾气虚证、肺阴虚证等。三证素组合多为痰热(29.07%)、痰瘀(24.42%)、痰湿(浊)(14.12%)等与病位肺的组合,表现为痰热壅肺证、痰瘀阻肺证、痰湿阻肺证等。四证素组合有痰热瘀阻肺证(3.38%)和外寒内饮证(0.85%)。其他组合有少阳郁热证(0.63%)、风痰入里证(0.42%)等。结论:弥漫性肺间质疾病的主要病理因素是痰(饮)、气虚、热、瘀血、阴虚、湿(浊)等,主要病位在肺、肾、脾等。Objective： To explore the distribution regularity of essential elements of TCM clinical syndrome of Diffuse Interstitial Lung Disease （DILD） through the investigation of cases hospitalized, and to guide TCM differentiation. Methods： Based on the requirements of TCM epidemiological investigation of DILD clinical research, Diffuse Interstitial Lung Disease Clinical Survey Questionnaire was set up, and also the database of TCM essential elements and syndromes. SPSS 13.0 for windows software was adopted for statistical description. Results： In the 12 disease-character factors, phlegm （fluid） had the highest frequency （80.76%）, and qi-deficiency, heat, blood stasis, yin deficiency and wet （moisture） followed with their frequency 50.95%, 41.44%, 33.62%, 21.56% and 19.24%. The main syndrome located the lung with the frequency 93.23%, then the kidney and the spleen, with their frequencies 36.79% and 7.61%. In the combinations of the factors, syndrome of single essential elements was syndrome of blood stasis （13.18%）. In the combination of a character elements and target points, qi-deficiency calculated 84.44%, and yin-deficiency 49.44%, yang-deficiency 3.89%, located on the lung, the kidney and the spleen, showed syndrome of lung qi deficiency, syndrome of kidney qi deficiency, syndrome of spleen qi deficiency, syndrome of lung yin deficiency, and others. In the combination of two character elements, there were syndrome of deficiency of both qi and yin （37.57%）, syndrome of deficiency of both yin and yang （1.66%） and syndrome of qi deficiency and blood stasis （0.55%）. In the combination of three elements, they showed the unions of phlegm-heat （29.07%）, phlegm-stasis （24.42%） and phlegm-wet （moisture） （14.12%） located in lung, and the main patterns were syndrome of phlegm-heat obstructing lung, syndrome of phlegm-stasis blocking lung, syndrome of phlegm-wet （moisture） locking lung and so on. In the combination of four elements, there were syndrome of phlegm-heat-st

关 键 词：弥漫性肺间质疾病 证素 临床调查 

分 类 号：R259[医药卫生—中西医结合]