老年高血压病合并不同类型CHD患者血清中NT-proBNP水平变化及意义  

Research and significance of CHD merger plasma NT-proBNP level of elderly primary hypertension patients with different types

作　　者：张小毅[1] 贾玲[1] 梁魏昉[1] 

机构地区：[1]郑州大学第一附属医院老年心血管科,郑州450052

出　　处：《医药论坛杂志》2011年第7期11-13,共3页Journal of Medical Forum

摘　　要：目的探讨在老年原发高血压病合并不同类型CHD患者的血浆中NT-proBNP的水平的变化及临床意义。方法用酶联免疫吸附法(ELISA)测定各组患者血清BNP浓度,共125例,①单纯原发性高血压病组35例,其中伴左心室肥厚(LVH组)15例,不伴左心室肥厚(NLVH)20例,采用多普勒超声计算左心室重量指数(LVMI)②高血压病合并阵发性房颤(AF)患者24例,③高血压病合并不稳定性心绞痛(UAP)患者23例,④高血压病合并急性心肌梗死型(AMI)13例,⑤30例正常人对照组,UAP、AMI诊断标准参考中华医学会心血管病学分会等制定的标准。根据生化检查、NYHA心功能分级以及超声检测排除肺疾病,心脏瓣膜病及肾功能不全,比较BNP在各组中的水平及差异。结果正常对照组BNP为(49.77±8.62)pg/ml,单纯高血压患者,高血压病合并阵发性房颤患者,高血压病合并不稳定性心绞痛患者,高血压病合并急性心肌梗死患者的BNP指标分别为(227.48±38.39)pg/ml,(612.75±139.44)pg/ml,(618.78±189.24)pg/ml,(1409.85±417,06)pg/ml,在高血压合并AMI组中BNP水平高于其他组,高血压病合并房颤及高血压合并不稳定性心绞痛患者BNP水平高于单纯性高血压患者,单纯性高血压患者BNP水平高于正常对照组(P<0.05)。高血压病合并LVH患者BNP水平高于高血压病合并NLVH患者及对照组水平,BNP和左心室肥厚存在正相关性。结论 BNP是高血压病、左心室肥厚、阵发性房颤及心肌损伤和坏死的很强预测指标。Objective To discuss the changes of levels of NT-proBNP clinical significance primary hypertension in elderly patients with different types of merger CHD plasma.Methods Enzyme immunosorbent adsorption method（ELISA） test each patient＇s serum BNP levels,there are 5 groups,①Pure primary hypertension group 35 cses,with left ventricular hypertrophy（group） LVH 15 cases,without left ventricular hypertrophy（20 cases NLVH）.②Hypertension merger paroxysmal AF patients（AF） 24 cases.③Hypertension merger unstable angina pectoris（UAP） patients 23 cases.④Hypertension complicating acute myocardial infarction（AMI） type 13 cases ⑤ 30 cases of normal control group.UAP,AMI diagnosis standard reference cardiovascular disease division of Chinese Medical Association.Results According to Biochemical examination,the cardiac function standard of New York Heart Association and Ultrasonic testing exclude chronic obstructive pulmonary disease,cardiac valve disease,unhealthy kidney function,compare the BNP in each level and differences.Conclusions BNP is a strong predictor of hypertension,left ventricular hypertrophy,paroxysmal af and myocardial injury and necrosis.

关 键 词：高血压病 NT-PROBNP 冠心病 

分 类 号：R544.1[医药卫生—心血管疾病]