慢性病态窦房结综合征与心阳虚血瘀病证结合模型研究  

Establishment of Rabbit Model of Sick Sinus Syndrome Combined with Heart-yang Deficiency and Blood Stasis Syndrome

作　　者：李汇博[1] 刘如秀[1] 王妮娜[1] 暴美静[1] 汪艳丽[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医药信息杂志》2011年第6期32-34,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(30873332)

摘　　要：目的探讨手术方法建立病态窦房结综合征(以下简称"病窦综合征")与心阳虚血瘀病证结合模型的可行性。方法采取冰敷、置于寒冷环境、皮下注射肾上腺素的方法制备非疾病阳虚血瘀证候模型;以20%甲醛注射浸润窦房结区建立慢性病窦综合征阳虚血瘀病证结合模型,观察2组兔造模前后一般情况、体温、呼吸频率、心率、心律、6 min游泳时间及速率、血液流变学(全血黏度、血浆黏度、红细胞聚集指数)等指标,根据中医临床阳虚血瘀证的诊断标准,对2种模型的中医证候特点进行比较。结果 2组兔造模后均出现体温下降、呼吸频率增快、心率减慢、游泳距离及速率降低、全血黏度、血浆黏度、红细胞聚集指数与正常组比较升高;且除心率、游泳距离及速率外,2组兔上述指标无明显差别。结论手术方法建立之慢性病窦综合征阳虚血瘀病证结合模型与非疾病阳虚血瘀证候模型在中医证候方面无明显差异,符合中医临床心阳虚血瘀证的诊断标准。Objective To explore the feasibility to establish a rabbit model of sick sinus syndrome combined with heart-yang deficiency and blood stasis syndrome（short as combined model）via surgery. Methods The TCM syndrome model was established by the method of ice wetting,cold stimulation and subcutaneous injection with adrenaline hydrochloride,and the combined model was established by damaging the sinoatrial node with 20%formaldehyde.The general state,body temperature,respiratory frequency,heart rate and rhythm,swimming distance and speed in 6 min,and hemorheology indexes were observed before and after the model of each group established.The TCM syndrome characteristics of the two models were compared according to the clinical diagnostic standard of yang deficiency and blood stasis syndrome.Results After the modle established,rabbits of both groups had lower temperature,higher respiratory frequency and heart rate,lower swimming distance and speed,and higher hemorheology indexes.There were no difference between the two groups in the indexes as mentioned except the heart rate,swimming distance and speed.Conclusion The combined model established by surgery has no difference with the TCM syndrome model in syndrome featrues,and it conforms to the clinical diagnostic standard of yang deficiency and blood stasis syndrome.

关 键 词：慢性病态窦房结综合征 动物模型 阳虚血瘀 病证结合 

分 类 号：R541.74[医药卫生—心血管疾病]