婴幼儿腺病毒肺炎T淋巴细胞亚群水平变化及其临床意义  

Study of immune function with Adenovirus pneumonia in infants

作　　者：林建国[1] 邓振悦[1] 

机构地区：[1]广东省南方医科大学附属新会区人民医院,529100

出　　处：《医学信息（下旬刊）》2011年第6期43-44,共2页Medical information

摘　　要：目的：通过检测腺病毒性肺炎患儿T淋巴细胞亚群水平状态,探讨腺病毒感染患儿的细胞免疫特点及其与该病发病的关系.方法：腺病毒性肺炎与非腺病毒性肺炎患儿各30例,采用链霉卵白素（SAP）法分别检测其T细胞亚群CD3、CD4、CD8阳性率及CD4/CD8比值,并对两组的检测结果进行比较.结果：腺病毒性肺炎患儿T淋巴细胞亚群水平与对照组比较,CD3、CD4水平降低,CD8水平增高,CD4/CD8比值减小,各观察指标的差异有显著性（P〈0.05）.结论：腺病毒感染可导致机体的免疫应答性降低,免疫应答功能紊乱.加强对病毒感染后免疫特点变化的研究,有利于对腺病毒性肺炎诊断及治疗水平的提高.Objective Detect T lymphocyte subsets of Adenovirus pneumonia in children, Found the characteristics of cellular immunity with adenovi- rus infection. Methods Selected 30 cases of adenovirus pneumonia in children, Detection the positive rate of T cell subsets CD3,CD4,CD8 using streptavidin （SAP） method. Compare the results between the two groups. Results The positive rate of T cell subsets CD3,CD4 was lower, CD8 was higher CD4/ CD8 was lower, the positive rate between the two groups had significant differences （P〈0.05）. Conclusion Virus infection can lead to decreased immune response, Dysfunction of the immune response. Strengthen the immune characteristics of virus infection, can increase the level of diagnosis and treatment.

关 键 词：婴幼儿 腺病毒 肺炎 T淋巴细胞亚群 

分 类 号：R725.6[医药卫生—儿科]