帕瑞昔布钠预注对异丙酚注射痛临床观察  

The effect of pretreatment with parecoxib on reducing pain induced by propofol Injection.

作　　者：戴贵茂[1] 张永洪[1] 

机构地区：[1]四川省绵阳市中心医院麻醉科,621000

出　　处：《医学信息（下旬刊）》2011年第6期143-144,共2页Medical information

摘　　要：目的：比较利多卡因和不同剂量帕瑞昔布钠预注对异丙酚注射痛临床效能.方法：160例Ⅰ～Ⅱ级拟行择期手术患者随机分为4组：帕瑞昔布钠20mg组（P20组）,帕瑞昔布钠40mg组（P40组）,利多卡因40 mg组（L组）和对照组（C组）.所有药物配制为5 ml,注入前阻断静脉2 min.药物注入外周静脉30 s后以0.5 ml/s的速度注射异丙酚（1%得普利麻）50 mg.异丙酚注射后观察和询问注射处有无疼痛,疼痛评分采用四分法.结果：4组疼痛评分有显著性差异（P＜0.01）.同C组中29例（58%）异丙酚注射痛相比,P20组22例（40%）,P40组有13例 （26%）（P＜0.05）.同对照组比较,P40组注射痛明显降低（P＜0.01）.C组中有18例（36%）发生中到严重疼痛,P20组有4例（8%）,P40组中则无中到严重疼痛（P＜0.01）.P20组和P40组疼痛程度显著降低P＜0.01）.结论：帕瑞昔布40 mg预注复合静脉阻断可有效减少异丙酚注射痛程度和发生率,而20mg可减轻疼痛程度,但并不减少发生率.Objective： To investigate the effect of parecoxib pretreatment with venous occlusion on propofol injection pain. Methods： 160 ASA physical status I or IX patients scheduled for elective surgery were randomized to four groups of 40 patients each to receive pretreatment with parecoxib 20 nag （Group F20）, or pareeoxib 40 mg （Group P40）, lidoeaine 40 mg （Group L） and normal saline （Group C）. All groups underwent venous occlusion for two minutes before pareeoxib was injected. All pretreatment drugs were prepared in 5 mL doses. Pain scores were obtained by a study--blinded observer during parecoxib injection following the different pretreatment solutions. Results： Pain scores among the three groups were significantly different （P 〈 0. 01）. In Group C, 29 （58%） patients had pain during propofol injection compared with 22 （40%） Group P20 and 13 （26%） Group P40 patients （P 〈0. 05）. Pain was significantly reduced in Group P40 （P 〈0.01） compared with the control group. Moderate to severe pain was experienced by 18 （36%） Group NS and 4 （8%） Group P20 patients, whereas no Group P40 patient experienced moderate or severe pain （P〈0.01）. Reduction in pain severity was statistically significant after pretreatment with either parecoxib 20 mg （P〈 0.01） or pareeoxib 40 mg （PG0.01）. Conclusion： Parecoxib 40 mg with venous occlusion is effective in reducing the frequency and severity of pain with parecoxib injection. Pretreatment with 20 mg of parecoxib reduces the severity of pareeoxib injection pain significantly but does not reduce frequency compared with the control group.

关 键 词：帕瑞昔布钠 异丙酚 注射痛 

分 类 号：R614[医药卫生—麻醉学]