当归补血汤及其服药后血清对小鼠造血祖细胞的影响  

Effects of Danggui Buxue Decoction and the Decoction-contained Serum on Granulocyte Macrophage Progenitor cell colony Forming Unit(GM-CFU)

作　　者：张英华[1] 武桂兰[1] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》1999年第6期30-32,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金!(3 963 0 3 60 )

摘　　要：当归补血汤煎液()对小鼠粒系—巨系造血祖细胞(CFU-GM)的生长有抑制作用,剂量越大,抑制作用越强。当归补血汤口饲小鼠后的含药血清()对CFU-GM的生长有明显的激活作用,剂量越大,CFU-GM集落生长的越多。药在相同含药血清浓度下,从时—效关系求出当归补血汤的药效动力学参数,Ke=0.3961/h,T1/2(Ke)=2.1602h,Ka=1.3422/h,T1/2(Ka)=1.6057h,Tp=1.5978h,Td=14.8019h。Danggui buxue decoction could inhibit growth of Granulocyte Macrophage Progenitor cell colony forming unit(GM CFU),and the more dose was,the less GM CFU was.But the decoction contained serum could promote growth of GM CFU,and the more dose was,the more GM CFU was.On the basis of the time effect cure gained from the decoction contained serum,pharmacokinetics parameters were as follows: Ke,T 1/2(ke) ,Ka,T 1/2(ka) ,Tp and Td was 0 3961/h,2 1602h,1 3422/h,1 6057h,1 5978h and 14 8019h,respectively.

关 键 词：当归补血汤 含药血清 药效动力学 CFU-GM 

分 类 号：R285.5[医药卫生—中药学]