黄芩苷对耐药性金黄色葡萄球菌的抑菌作用研究  

Experiment on bacteriostasis function of baicalin against methicilin-resistant staphlococcus aureus

作　　者：孙冬梅[1] 邝枣园[1] 李岩[1] 万幸[1] 李庆国[1] 李蔼文[2] 

机构地区：[1]广州中医药大学,广东广州510000 [2]广东省第二中医院检验科,广东广州510000

出　　处：《吉林医学》2011年第13期2587-2588,共2页Jilin Medical Journal

摘　　要：目的:研究黄芩苷对耐药性性金黄色葡萄球菌的抑菌作用。方法:通过体外对耐药性性金黄色葡萄球菌的抑菌试验及体内对耐药性性金黄色葡萄球菌感染小鼠的保护作用,观察黄芩苷的抑菌作用。结果:体外试验表明黄芩苷、复方磺胺甲噁唑(SMZ-TMP)对耐药性金黄色葡萄球菌的最低抑菌浓度分别是2 mg/m、l0.45 mg/m。l体内试验表明黄芩苷(100 mg/kg)可以降低耐药性金黄色葡萄球菌感染小鼠的死亡率。结论:黄芩苷对耐药性金黄色葡萄球菌有抑菌作用。Objective To examine the bacteriostasis of baicalin against methicilin-resistant Staphlococcus aureus（MRSA）.Method In vitro on MRSA and in vivo antibacterial test against MRSA infection in mice,observation baicalin bacteriostasis.Results In vitro antibacterial test showed that the minimum inhibitory concentration of baicalin and compound sulfamethoxazole for MRSA were 2 mg/ml,0.45 mg/ml respectively and in vivo inhibition experiments showed that baicalin（100 mg/kg） had decreased the mortality of MRSA infection in mice,that this drug had antimicrobial effect.Conclusion Baicalin has antibacterial effect.

关 键 词：黄芩苷 耐药性金黄色葡萄球菌 抑菌作用 

分 类 号：R285[医药卫生—中药学]