血脂调节药依托贝特的合成  

Synthesis of Lipid-lowing Drug Etofibrate

作　　者：孟兰起 张徐岩 赵鑫[3] 

机构地区：[1]沈阳市化工学校,辽宁沈阳110122 [2]沈阳燃气有限公司,辽宁沈阳110005 [3]辽宁省药物研究院,辽宁沈阳110015

出　　处：《当代化工》2011年第5期465-466,共2页Contemporary Chemical Industry

摘　　要：以2-(4-氯苯氧基)-2-甲基丙酸为起始原料,与1,2-乙二醇在磷酸和对甲苯磺酸作用下,120℃温度下反应3 h,生成酯后,再与烟酰氯反应合成目标物依托贝特,通过红外光谱及元素分析确证其结构。Etofibrate was synthesized by reaction of nicotinic acid chloride and 2-[2-（4-chlorophenoxy）-2-methyl-propionyl]-2-hydroxyethylester obtained from 2-（4-chlorophenoxy）-2-methyl-propionic acid by esterifcation with glycol in the presence of 85% phosphoric acid and p-toluene sulfonic acid at 120 ℃ for about 3 h.The chemical structure of the target compound was confirmed by IR and element analysis

关 键 词：依托贝特 合成 降血脂药物 

分 类 号：TQ422[化学工程]