外周血p53基因多态性与中国人瘢痕疙瘩相关性的Meta分析  

Correlation between p53 Codon 72 Polymorphism in Peripheral Blood and Keloid in Chinese Population:A Meta-analysis

作　　者：吴严[1] 刘佳丽[2] 陈晶[1] 孙艳[1] 李远宏[1] 高兴华[1] 陈洪铎[1] 

机构地区：[1]中国医科大学附属第一医院皮肤科,沈阳110001 [2]中国医科大学附属第四医院肿瘤科,沈阳110001

出　　处：《中国循证医学杂志》2011年第6期651-654,共4页Chinese Journal of Evidence-based Medicine

基　　金：2007年教育部创新团队基金(编号:IRT0760)

摘　　要：目的系统评价外周血中p53基因第72密码子多态性与中国人瘢痕疙瘩的相关性。方法计算机检索PubMed、EBSCO、CNKI、CBM及万方数据库,收集外周血中p53基因第72密码子多态性与中国人瘢痕疙瘩相关性的病例对照研究。检索时间为建库至2010年8月。用Meta分析方法综合评价外周血中p53基因第72密码子基因型Pro/Pro vs.Arg/Arg、Pro/Pro vs.Pro/Arg及等位基因型Pro vs.Arg在中国人瘢痕疙瘩组与对照组中是否有差异。结果共纳入5个研究,包括瘢痕疙瘩患者328例及对照420例。Meta分析结果显示:具有基因型Pro/Pro的中国人群发生瘢痕疙瘩的风险与具有基因型Arg/Arg[OR=2.17,95%CI(0.86,5.47)]或基因型Pro/Arg[OR=1.90,95%CI(0.92,3.93)]的人群相当,而等位基因Pro引起瘢痕疙瘩发病风险高于等位基因Arg[OR=1.86,95%CI(1.03,3.35)]。结论中国人外周血中p53基因第72密码子等位基因Pro与瘢痕疙瘩发病有关。To clarify the correlation of p53 codon 72 polymorphism in peripheral blood with keloid susceptibility in Chinese population. Methods All the literatures of case-control research on the correlation between p53 codon 72 polymorphism in peripheral blood and keloid in Chinese population were searched in PubMed, EBSCO, CNKI, CBM, and WanFang Data from their establishment to August 2010. Meta-analyses were performed to detect whether there were differences between the keloid group and the control group about the distribution of genotypes of p53 codon 72 in peripheral blood, such as, Pro/Pro vs. Arg/Arg, Pro/Pro vs. Pro/Arg, and alleles Pro vs. Arg. Results Five studies involving 328 keloid patients and 420 patients in the control group were included. The results of meta-analyses showed that the population having the genotype Pro/Pro presented no increased keloid risk compared to that with the genotypes Arg/Arg （OR=2.17, 95%CI 0.86 to 5.47） or Pro/Arg （OR=1.90, 95%CI 0.92 to 3.93）, while the allele Pro showed significant association with increased keloid risk compared to the allele Arg （OR=1.86, 95%CI 1.03 to 3.35）. Conclusion The allele Pro of p53 codon 72 in peripheral blood of Chinese population is significantly associated with increased keloid risk.

关 键 词：P53 多态性 瘢痕疙瘩 META分析 中国人群 

分 类 号：R622[医药卫生—整形外科]