血清超敏C反应蛋白和肿瘤坏死因子α水平检测在妊娠糖尿病患者中的临床意义  

Clinical significance of determination of changes of serum high sensitivity C-reactive protein and tumor necrosis factor alpha levels in patients with gestational diabetes mellitus

作　　者：王慧[1] 罗炜[1] 廖伟娇[1] 刘汉欣[1] 向波[1] 范婷婷[1] 

机构地区：[1]广州医学院附属第一医院,510120

出　　处：《国际检验医学杂志》2011年第7期753-754,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨妊娠糖尿病(GDM)患者血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)的变化以及与胰岛素抵抗(IR)之间的关系。方法检测35例正常糖耐量孕妇(NGT)组、32例妊娠期糖耐量受损孕妇(IGGT)组及32例妊娠糖尿病孕妇(GDM)组血清hs-CRP、TNF-α水平,并用稳态模型分析法计算胰岛素抵抗指数(HOMA-IR)。结果 GDM组hs-CRP、TNFα-、HOMA-IR均高于IGGT组和NGT组,差异有统计学意义(P<0.05)。Pearson相关分析显示,hs-CRP、TNF-α与HO-MA-IR呈显著相关性(r=0.282,P<0.01;r=0.461,P<0.01)。结论血清hs-CRP、TNF-α升高与GDM患者胰岛素抵抗关系密切,是GDM发生、发展的重要影响因素。Objective To investigate the association of serum concentration of high sensitivity C-reactive protein（hs CRP）and tumor necrosis factor alpha（TNF-α with insulin resistance in women with gestational diabetes mellitus（GDM）. Methods The lev els of hs CRP and TNF-α from 35 pregnant women with normal glucose tolerance（NGT group）,32 pregnant women with impaired glucose gestational tolerance（IGGT group）and 32 pregnant with gestational diabetes mellitus（GDM group）were detected. Homeo stasis model assessment was used to evaluate indexes of insulin resistance. Results hs-CRP, TNF-αand HOMA IR in the GDM group were significantly higher than those in the IGGT and NGT group（P〈0.05）. Pearson correlation analysis showed that hs CRP and TNF-α were positively correlated with HOMA-IR（r=0. 282,P〈0.01;r=0. 461,P〈0.01）. Conclusion The levels of hs-CRP and TNF-αincrease in women with GDM, which are closely related to insulin resistance and are the important factors in the pathogenesis of GDM.

关 键 词：C反应蛋白质 肿瘤坏死因子Α 糖尿病 妊娠 

分 类 号：R714.256[医药卫生—妇产科学]