糖尿病患者免疫功能状态研究  

The study for immunologic function of diabetic patient

作　　者：杨伟国[1] 居军[1] 

机构地区：[1]甘肃省临床检验中心,兰州730000

出　　处：《国际检验医学杂志》2011年第7期768-769,共2页International Journal of Laboratory Medicine

摘　　要：目的通过对糖尿病患者与健康对照者的体液免疫功能、细胞免疫功能及红细胞免疫黏附功能进行比较,了解糖尿病患者的免疫功能状态。方法利用BN-Ⅱ型特种蛋白仪和流式细胞仪对患者及健康对照者行体液免疫和细胞免疫功能的检测。结果糖尿病患者除IgA有不同程度的升高外,无论是体液免疫功能还是细胞免疫功能都明显降低,而且红细胞的免疫黏附功能发生明显变化,与健康对照组比较差异有统计学意义(P<0.05)。结论糖尿病患者细胞免疫功能不同程度的降低,其胰岛功能受损也是造成免疫功能降低的重要原因。Objective To investigate humoral immunologic function, cellular immunologic function and RBC adhesion immune function of diabetic patient. Methods Flow cytometry and nephelometry were applied to evaluate cellular and humoral immunologic function of diabetic patient respectively. Results Both RBC adhesion immune function,cellular and humoral immunologic function of diabetic patient were significantly lower than those of healthy controls,while the label of lgA of diabetic patient were higher than controls. Conclusion The immunologic function of diabetic patient was destroied to a certain extent by hyperglycemia and,some how, by the impaired islet function.

关 键 词：糖尿病 细胞黏附 细胞免疫功能 体液免疫功能 

分 类 号：R587.1[医药卫生—内分泌]