血清GPI、CRP在活动期类风湿关节炎中的诊断意义  

Applicaton of Serum Glucose-6-Phosphate Isomerase and C-reactive Protein in Diagnosis of Activated Rheumatoid Arthritis

作　　者：杨淑娟[1] 彭俊华[1] 李泽慧[1] 胡秦妮[1] 

机构地区：[1]兰州军区兰州总医院检验科,甘肃兰州730050

出　　处：《甘肃科学学报》2011年第2期45-47,共3页Journal of Gansu Sciences

摘　　要：探讨葡萄糖6磷酸异构酶(GPI)、C反应蛋白(CRP)在类风湿关节炎(RA)中的临床意义.研究采用酶联免疫方法检测人血清中的GPI浓度,用散射比浊法测血清CRP浓度.结果显示RA患者GPI、CRP水平分别为(2.05±1.85)mg/L、(25.3±8.24)mg/dL,GPI、CRP阳性率分别为64.29%、71.43%,均明显高于健康对照组[(0.18±0.05)mg/L、(2.5±0.18)mg/dL,2.73%、3.76%],RA活动期GPI、CRP水平明分别为(2.45±2.21)mg/L、(59.3±8.28)mg/dL,明显高于非活动期[(1.75±1.25)mg/L、(6.6±0.57)mg/dL],治疗后GPI、CRP水平分别为(1.35±1.05)mg/L、(8.6±0.87)mg/dL,明显降低.因此,检测GPI、CRP是早期诊断RA、判断RA疗效,可预测RA愈后指标,可在临床中推广应用.The diagnostic value of glucose-6-phosphate isomerase（GPI） and c-reactive protein（CRP） were explored in diagnosis of activated rheumatoid arthritis（PA）.The level of serum GPI was detected by ELISA,and the level of serum CRP was detected by scattering immunoturbidimetric assay.Our results showed that the levels of serum GPI and CRP in RA patients were（2.05±1.85） mg/L and（25.3±8.24） mg/dL,respectively.The positive rates of GPI and CRP of RA patients were 64.29% and 71.43%,respectively.They were significantly increased than those in healthy control（0.18±0.05） mg/L,（2.5±0.18 mg/dL,2.73%,3.76%）.The levels of serum GPI and CRP in activated RA patients were（2.45±2.21） mg/L and（59.3±8.28） mg/dL,respectively.They were significantly increased than those in non-activated RA（（1.75±1.25） mg/L,（6.6±0.57） mg/dL）.The levels of serum GPI and CRP after treatment were（1.35±1.05） mg/L and（8.6±0.87） mg/dL,respectively;they were significantly decreased than those in non-treatment RA.The conclusion is that detecting serum GPI and CRP was a symbol of diagnosing RA early,assessing treatment outcome and predicting treatment result.They can be popularized and applyied in clinical detection.

关 键 词：类风湿关节炎 葡萄糖6磷酸异构酶 C反应蛋白 

分 类 号：R446.11[医药卫生—诊断学]