姜黄素衍生物FM0807的溶解特性与稳定性影响因素考察  

Factors Influencing the Solubility and Stability of Curcumin Derivative-FM0807

作　　者：王晓露[1] 许建华[1] 邓艳平[1] 黄秀旺[1] 吴敏[1] 郭晓丹[1] 魏晓霞[1] 

机构地区：[1]福建医科大学药学院,福州350004

出　　处：《福建医科大学学报》2011年第2期106-108,共3页Journal of Fujian Medical University

基　　金：福建省科技重点项目(2009Y0025);福建省产业技术开发项目[闽发改高技(2008)264号]

摘　　要：目的研究姜黄素(Cur)衍生物FM0807的溶解特性与稳定性影响因素,为后续药效学研究奠定基础。方法在高温、高湿、强光照射条件下进行影响因素试验;利用HPLC测定FM0807在不同pH值缓冲液中水解动力学、油/水分配系数以及在不同溶液中的溶解度。结果 FM0807在高湿环境下较稳定,高温条件下有少量降解,强光照射下不稳定;在0.1 mol/L盐酸溶液中极微溶,在pH 6.8磷酸盐缓冲液和去离子水中几乎不溶;在不同pH值缓冲液中较稳定;不同pH值条件下表观油/水分配系数的对数值多在1～2之间,亲脂性较亲水性高。结论 FM0807为不易溶解物质,稳定性优于母核Cur。Objective To assay factors which affect the solubility and stability of FM0807,laying the foundation for researches of the pharmacodynamics for the follow-up study.Methods High Performance Liquid Chromatography（HPLC） are used to measure stability kinetics of FM0807 in solutions with different pH values,solubility,and oil/water partition coefficient.Results FM0807 was very stable in the environment of high humidity,and its degradation was undetectable until the tenth day under high temperature,and it is unstable under light.FM0807 is more stable than its precursor-curcumin.The oil/water partition coefficient of FM0807 fell in the interval of in buffer solutions with different pH values.Conclusion FM0807 is insoluable and more stable than the prodrug of curcumin.

关 键 词：姜黄素 药物稳定性 水解作用 

分 类 号：R285[医药卫生—中药学]