系统性红斑狼疮患者早发动脉粥样硬化的临床研究  

The Clinical Study of Atherosclerosis Praecox in Patients with Systemic Lupus Erythematosus

作　　者：薛原[1] 王贞[1] 孔瑞[1] 康日辉[1] 林珺芳[1] 陈君敏[1] 

机构地区：[1]福建医科大学附属第一医院风湿血液科,福州350005

出　　处：《福建医科大学学报》2011年第2期140-142,共3页Journal of Fujian Medical University

基　　金：福建省教育厅基金(JB08085)

摘　　要：目的评估系统性红斑狼疮(SLE)早发动脉粥样硬化的情况。方法选取SLE患者中未绝经女性44例,并以健康青中年女性31例作为对照,检测2组患者的颈动脉内膜中层厚度(CIMT)及臂踝脉搏波速度(baP-WV),并进行统计学比较。结果 CIMT检查,SLE组中有2例存在颈动脉斑块(CAP),年龄分别为45、49岁,且病程均>5年,而对照组无CAP形成;SLE组CIMT及baPWV均较对照组明显增高(P<0.05);CIMT、baPWV在SLE组中病程是否≥5年组、是否疾病活动组、是否伴高血压组中比较差别均有统计学意义(P<0.05)。结论 SLE患者有明显的动脉粥样硬化倾向;疾病病程、是否伴高血压是动脉粥样硬化的重要危险因素。Objective To estimate the level of atherosclerosis praecox in patients with systemic lupus erythematosus.Methods The levels of brachial-ankle pulse wave velocity and carotid intima media thickness in 44 patients with systematic lupus erythematosus are compared with those in 31 healthy controls statistically.Results There are two cases with CAP in patients with SLE（45 years old and 49 years old respectively with more than 5 years disease duration）,while there is none similar case in healthy controls.The levels of baPWV and CIMT in patients with SLE are higher than healthy controls（P〈0.05）.The levels of baPWV and CIMT have statistical significance in SLE patients group with or without hypertention and the disease duration of more than or less than 5 years（P〈0.05）.Conclusion SLE patients present obvious tendency of atherosclerosis compared with healthy controls;the disease duration,hypertension play important roles in the duration of atherosclerosis.

关 键 词：红斑狼疮 系统性 动脉粥样硬化 脉搏 颈动脉 血管内膜 

分 类 号：R593.241.06[医药卫生—内科学]