HCV Core蛋白与IFN敏感性相关结构及功能的生物信息学分析  

Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV Core protein

作　　者：程玲[1] 郭艳[1] 洪国祜[1] 毛青[1] 

机构地区：[1]第三军医大学西南医院全军感染病研究所,重庆400038

出　　处：《中华实验和临床病毒学杂志》2011年第2期96-98,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的生物信息学工具分析不同基因型HCVCore蛋白与IFN敏感性相关的结构功能及差异。方法应用生物信息学工具对不同基因型HCVCore蛋白二级结构、三级结构、修饰位点及主要功能结构域预测分析。结果HCVCore蛋白氨基酸序列、二级结构、三级结构各型间存在差异，可能存在酰胺化、cAMP依赖的激酶、PKC、TYR磷酸化等修饰位点及与两性蛋白SH3结构域、ERK、PKC相互作用的区域。结论不同基因型HCVCore蛋白结构功能不同影响IFN治疗敏感性。Objective To analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes. Methods Using different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein. Results There were diversities in secondary structure and tertiary structure of different genotypes. HCV Core protein would exist some modification sites about amidation, cAMP, PKC, TYR, and interact with amphiphysin SH3 domain, ERK, PKC. Conclusion Differences in structure and function of HCV Core protein of different genotypes affected interferon sensitivity.

关 键 词：肝炎 丙型 病毒核心蛋白质类 生物信息学分析 基因 结构 干扰素类 

分 类 号：R373.21[医药卫生—病原生物学]