^(18)F-FDG符合线路SPECT/CT对肺孤立性病变的诊断价值  

Diagnostic value of ^(18)F-FDG SPECT/CT coincidence detection imaging for solitary pulmonary mass

作　　者：陆武[1] 刘永[1] 宋长祥[1] 经丰琴[1] 

机构地区：[1]连云港市第一人民医院核医学科,江苏222002

出　　处：《放射学实践》2011年第5期560-563,共4页Radiologic Practice

基　　金：连云港市卫生局资助课题(09053)

摘　　要：目的:应用18F-脱氧葡萄糖(18F-FDG)符合线路SPECT/CT显像半定量分析,探讨符合线路SPECT/CT对肺部孤立性病变的诊断价值。方法:回顾性分析经病理或随访证实的74例肺孤立性病变患者的18F-FDG符合线路SPECT/CT图像,用半定量法(计算病灶组织与周围正常软组织的摄取比值,即T/NT)测量,所得数据进行统计学分析。结果:半定量分析显示恶性病变摄取18F-FDG比值(9.57±6.13)明显高于良性病变(2.99±1.59),差异有统计学意义(P<0.05)。以T/NT≥3.5作为恶性病变的判定标准,74例肺孤立性病变中,真阳性49例,真阴性16例,假阳性7例,假阴性2例。敏感度、特异度、准确率、阳性预测值和阴性预测值分别为96.08%、69.57%、87.84%、87.50%和88.89%。结论:18F-FDG符合线路SPECT/CT显像对肺孤立性病变的诊断、鉴别诊断及预后评估具有重要的临床应用价值。Objective：The aim is to explore the clinical value of ^18F-fluorodeoxyglucose（^18F-FDG） coincidence detection imaging for solitary pulmonary mass using semi-quantitative analysis of SPECT/CT CoDe imaging.Methods：Seventy-four cases of solitary pulmonary mass,which were confirmed by pathologic findings or follow-up,were checked by ^18F-FDG SPECT/CT CoDe imaging.The findings of ^18F-FDG metabolic images were analyzed in semi-quantitative ways.Regions of interest（ROI） were placed over the mass（T） and normal soft tissue（NT）,and T/NT value was calculated.Results：Of the 74 cases,49 were true positive cases,16 true negative cases,7 false positive and 2 false negative according to T/NT≥3.5 threshold.A sensitivity of 96.08%,a specificity of 69.57%,and an accuracy of 87.84% were found for detection of pulmonary neoplasm.The positive prediction value（PPV） and negative prediction value（NPV） were 87.50% and 88.89%,respectively.The ^18F-FDG uptaking value in malignant disease was higher than in benign lesions（P〈0.05）.Conclusion：Semi-quantitative analysis of SPECT/CT CoDe imaging is of important clinical value in early detection,differential diagnosis and prognosis evaluation for solitary pulmonary mass.

关 键 词：氟脱氧葡萄糖F18 体层摄影术 发射型计算机 电子 肺疾病 体层摄影术 X线计算机 

分 类 号：R816.41[医药卫生—放射医学]