肾移植术后牙龈增生的临床分析  

The Clinical Analysis of Gingival Hyperplasia in Patients after Renal Transplantation

作　　者：马小平[1] 刘洋[1] 李阳波[1] 许亚宏[1] 林涛[2] 

机构地区：[1]中国人民解放军第四五二医院泌尿外科,成都610021 [2]四川大学华西医院泌尿外科

出　　处：《华西医学》2011年第5期695-697,共3页West China Medical Journal

摘　　要：目的探讨肾移植术后药物(环孢素A和钙离子拮抗剂)、口腔卫生与牙龈增生的关系。方法随访2003年1月—2010年3月间321例肾移植患者,记录患者术后药物使用和口腔卫生情况,观察牙龈增生程度。结果口腔卫生水平与牙龈增生程度之间存在统计学相关性(rs=0.344,P=0.000),口腔卫生水平越差,牙龈增生越严重。服用环孢素A和钙离子拮抗剂患者(A组)牙龈增生发生率为62.15%,高于单纯服用环孢素A患者(B组)23.40%,二者比较,差异有统计学意义(χ2=39.220,P=0.000)。结论肾移植术后环孢素A和钙离子拮抗剂联合应用明显增加了牙龈增生的发病率。口腔卫生水平与牙龈增生程度之间存在重要关联,口腔卫生差是牙龈增生的危险因素。Objective To investigate the correlation between drugs（cyclosporine A and calcium channel blocker）,oral hygiene and gingival hyperplasia in patients after renal transplantation.Methods We continuously followed up 321 patients undergoing renal transplantation from January 2003 to July 2009 in our hospital.The levels of oral hygiene,medication and gingival hyperplasia were recorded.Results There was a close relationship between the level of oral hygiene and the degree of gingival hyperplasia（rs=0.344,P=0.000）.Higher grades of gingival hyperplasia（grades Ⅱ and Ⅲ） were found exclusively in patients who did not have good oral hygiene.There was a higher tendency of developing gingival hyperplasia among patients who received cyclosporine A and calcium channel blocker than those who only received cyclosporine A（62.15% vs.23.40%;χ2=39.220,P=0.000）.Conclusion The prevalence of gingival hyperplasia is higher in renal transplant recipients taking cyclosporine A and calcium channel blockers.There is a significant relationship between the level of oral hygiene and the development of gingival hyperplasia.Poor oral hygiene is a risk factor of gingival hyperplasia.

关 键 词：肾移植 环孢素A 牙龈增生 口腔卫生 

分 类 号：R699.2[医药卫生—泌尿科学]