一体化妇科吊带的力学性能及生物相容性评价  

Biocompatibility and Mechanical Properties of Support Sling for Female Urinary Stress Incontinence

作　　者：黄建艳 谢佩仪 赵能育 徐斌 徐国风 

机构地区：[1]广东冠昊生物科技股份有限公司再生植入医疗器械国家工程实验室,广东广州510663

出　　处：《材料科学与工程学报》2011年第3期425-428,共4页Journal of Materials Science and Engineering

摘　　要：目的：探讨应用新的组织处理技术研制的一体化妇科吊带的力学性能及生物相容性。方法：以动物的膜材料及肌腱为原料,经脱细胞、环氧固定及表面修饰技术处理,制备成一体化妇科吊带,进行拉伸试验及植入试验评价其力学性能及生物相容性。结果：各种型号的一体化妇科吊带均有良好的力学性能,最大拉力及抗拉强度随悬吊带的宽度和长度而异,其中抗拉强度为11.47~28.82 MPa;植入实验表明一体化妇科吊带稳定性高,生物相容性好,未引起宿主免疫排异反应,植入后只是在周围组织中引起轻度的异物反应,很快与宿主组织长合为一体,促进纤维组织长入。结论：应用新的组织处理技术研制的一体化妇科吊带,有效地去除了动物异种蛋白的免疫原性,具有良好的力学性能,在宿主体内组织相容性好,加上外形的特别设计使其使用简便,有望成为压力性尿失禁患者盆底重建的理想替代材料。To investigate the biocompatibility and mechanical properties of support sling for female urinary stress incontinence prepared by novel biotech,support sling was prepared by fresh porcine membrane and tendons with acellular process,epoxy cross-linking fixation and surface activating process.Then the biocompatibility and mechanical properties were evaluated by tensile test and animal test.The tensile test showed that the mechanical properties were feasible for support female urinary stress,which maximum tension and tension-resistant strength were different according to the length and width of the sling.And tension-resistant strength was between 11.47-28.82 MPa.The sling showed good biocompatibility and high stability without immunologic rejection after implanting in the goats＇ muscle of abdominal wall except for slight foreign body reaction,and new tissues were grown into the core of the mesh.Prepared by the new biotech,support sling for female urinary stress has good biocompatibility and mechanical properties without immunogenic.Its specialized design makes it easily to use and a promising substitute for female urinary stress.

关 键 词：一体化妇科吊带 力学性能 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]