糖尿病患者低密度脂蛋白与内皮细胞受体结合的研究  

Study on binding capacity of low-density lipoprotein to its receptors in diabetic patients

作　　者：林东平[1] 仰礼真[1] 潘晓骅[2] 姜博仁[1] 郭郁郁[1] 朱惠[1] 雷涛[3] 陆颖理[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院内分泌科, 200011 [2]上海交通大学医学院附属第九人民医院检验科(, 200011 [3]上海同济大学附属同济医院内分泌科

出　　处：《中华内分泌代谢杂志》2011年第5期418-419,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：用荧光法检测正常组、糖尿病HbA1c〈7．0％组和HbA1c〉7．0％组的低密度脂蛋白（LDL）糖化值分别为（17．7±2．31）、（34．29±5．73）和（48．79±7．82）Glycogroups／LDL，用酶联免疫受体法检测上述3组LDL与人内皮细胞LDL受体的特异结合活性分别为（37．65±5．20）、（27．36±4．34）和（15．07±2．23）ng／mg细胞蛋白，2组糖尿病的LDL糖化值均高于对照组（P〈0．01），HbA1c〉7．O％组高于HbA1c〈7．0％组（P〈0．01），而LDL与其受体结合的结果相反。[ Summary] The levels of low-density lipoprotein （LDL） glycation from control group, diabetic HbA1c 〈 7.0% , and HbA1c〉7.0% groups were （ 17.7±2.31 ） , （34.29±5.73） , and （48.79±7.82） Glycogroups/LDL by fluorimetry. The LDL binding to its receptor in three groups were （37.65±5.20） , （27.36±4.34）, and （ 15.07± 2.23 ）ng/mg cell protein measured by enzyme-linked immunoreceptor assay. The glycated levels in two diabetic groups were higher than that in control group, and higher in HbA1c〉7.0% group than in HbAlc〈7.0% group （ all P〈 0. 01 ）. The results of LDL binding capacity to its receptor were just the opposite.

关 键 词：糖尿病 脂蛋白类 低密度 受体结合 

分 类 号：R587.1[医药卫生—内分泌]