乳杆菌LB散联合三联疗法治疗幽门螺杆菌感染的疗效  

Effects of triple therapy combined with lactobacillus LB sachet on Helicobacter pylori infection

作　　者：周刚[1] 李之印[1] 王仲略[1] 沈慧琳 

机构地区：[1]杭州市第二人民医院消化科,浙江杭州310015

出　　处：《中国新药与临床杂志》2011年第5期362-364,共3页Chinese Journal of New Drugs and Clinical Remedies

基　　金：浙江省自然科学基金(y2080675)

摘　　要：目的观察乳杆菌LB散联合传统三联疗法治疗幽门螺杆菌(Hp)感染的疗效及不良反应,探讨Hp治疗新途径。方法选择90例Hp阳性的慢性胃炎、消化性溃疡患者分为对照组(雷贝拉唑、克拉霉素、阿莫西林三联疗法)和治疗组(乳杆菌LB散联用三联疗法),疗程均为2wk。每周调查1次患者的不良反应情况及其耐受程度。治疗结束4wk后复查^(14)C-尿素呼气试验和尿素酶试验,判断根除Hp疗效。结果 Hp的根除率按ITT分析及PP分析,对照组为71%和78%,治疗组为89%和93%(P<0.05);治疗组胃肠道不良反应低于对照组(P<0.05)。结论乳杆菌LB散联合三联疗法是根除Hp的一种有效方法,且能够显著减少三联疗法的胃肠道不良反应。AIM To observe the effects of triple therapy combined with lactobacillus LB sachet on Heli- cobacter pylori （Hp） infection. METHODS Ninety Hp positive patients with peptic ulcer or chronic gastritis were randomly divided into two groups. The patients in the control group were treated with triple therapy consisting of rabeprazole, clarithromycin and amoxicillin, and patients in the trial group were treated with triple therapy combined with lactobacillus LB sachet for 14 days. The adverse reactions questionnaire was filled in once a week. Four week after the treatment 14C-urea breath test and urease test was performed to determine the effect of Hp eradication. RESULTS By ITI＂ analysis and PP analysis, the eradication rates were 71% and 78% in the control group, 89% and 93% in the trial group （P 〈 0.05）. The gastrointestinal adverse reactions in the trial group were fewer than that in the control group （P 〈 0.05）. CONCLUSION Triple therapy combined with lactobacillus LB sachet is effective in the treatment of Hp infection, and can reduce the gastrointestinal adverse reactions significantly.

关 键 词：乳杆菌LB散 螺杆菌 幽门 药物疗法 联合 消化性溃疡 胃炎 质子泵抑制剂 

分 类 号：R975[医药卫生—药品]