益肾生血片对再生障碍性贫血模型小鼠造血细胞作用的研究  

Effect of Yishen Shengxue Tablet on Hematopoietic Cells of Aplastic Anemia Mice Model

作　　者：许勇钢[1] 麻柔[1] 王洪蓓[1] 王展翔[1] 王洪志[1] 周霭祥[1] 廖军鲜[2] 钟明华[2] 

机构地区：[1]中国中医研究院西苑医院血液病研究室,北京100091 [2]中日友好医院,北京100029

出　　处：《中国中医基础医学杂志》1999年第11期23-26,共4页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的　探讨益肾生血片(YSSXT)治疗再生障碍性贫血(AA)的作用机理。方法　用马利兰造成小鼠AA模型,观察该药对AA模型小鼠造血细胞的作用。结果　显示益肾生血片对马利兰引起的造血损伤小鼠骨髓造血干细胞(CFUmix)、粒系祖细胞(CFU-GM)、红系祖细胞(CFU-E)、有核细胞(MNC)计数、巨核细胞计数和外周血白细胞、血色素和血小板数量的恢复有明显促进作用。结论　保进骨髓造血干细胞增殖是益肾生血片治疗AA的机制之一。To study the therapeutic mechanism of Yishen Shengxue Tablet (YSBXT) for Aplastic anemia (AA).Methods:Aplastic Anemia Mice Model was produced by administering Busulfan.Effect of YSBXT on hematopoietic cells of AA micemodel was observed.Results:YSBXT significantly enhanced the MNCs、CFUmix、CFU-GM and CFU-E yields of AA mice bone marrow;it also increased the WBC、Hb、RBC and PLT count in AA mice.Conclusions:Accelereting the proliferation of hematopoietic cells is one of mechanisms in treating AA with YSBXT.

关 键 词：益肾生血片 再生障碍性贫血 造血细胞 模型小鼠 

分 类 号：R259.565[医药卫生—中西医结合]