SUMO化信号途径对JNK信号通路活性的调控  

The Sumoylation Pathway Modulates JNK Signaling in Drosophila

作　　者：黄海[1,2] 朱南南[1,2] 焦仁杰[1] 

机构地区：[1]中国科学院生物物理研究所,北京100101 [2]中国科学院研究生院,北京100049

出　　处：《生物化学与生物物理进展》2011年第6期568-574,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31071087);国家重点基础研究发展计划(973)(2009CB918702)资助项目~~

摘　　要：c-Jun氨基末端激酶(the c-Jun N-terminal kinase,JNK)家族是促分裂原活化蛋白激酶(MAPK)超家族成员之一.JNK信号通路对细胞生长、分化和凋亡等生物学活动都有重要作用.而SUMO化是一种重要的生物学修饰,可以调节多种细胞生理活动.最近,黄海等在Development发表文章首次将SUMO化途径与JNK信号通路通过Hipk激酶联系起来,为进一步研究SUMO化的功能及其对JNK通路的调节建立了一个新的模型.The c-Jun N-terminal kinase, JNK, is one of the mitogen-activated protein kinase superfamily members. JNK signaling pathway plays important roles in a variety of biological activities such as cell growth, differentiation and apoptosis. Post-translational modification by the small ubiquitin-related modifier （SUMO）, termed as sumoylation, regulates multiple cellular and physiological processes. A very recent report in Development by Huang et al. establishes a link between sumoylation pathway and JNK pathway through the action of homeodomain-interacting protein kinase （Hipk）, which advances our understanding of the JNK signaling regulation in Drosophila.

关 键 词：JNK通路 SUMO化 Hipk 

分 类 号：Q25[生物学—细胞生物学]