重离子束辐照对荷颊囊癌金黄地鼠血清微量元素的影响  

Effect of Heavy Ion Beam on Concentrations of Trace Elements in Serum of Golden Hamster with Cheek Pouch Carcinoma

作　　者：张宝平[1] 张红[2,3,4] 张晓文[5] 张格祥[1] 王小虎[5] 刘阳[2,3,4] 刘斌[1,2,3,4] 

机构地区：[1]兰州大学口腔医学院,甘肃兰州730000 [2]中国科学院近代物理研究所,甘肃兰州730000 [3]中国科学院重离子束辐射生物医学重点实验室,甘肃兰州730000 [4]甘肃省重离子束辐射医学应用基础重点实验室,甘肃兰州730000 [5]甘肃省肿瘤医院,甘肃兰州730050

出　　处：《原子核物理评论》2011年第2期225-229,共5页Nuclear Physics Review

基　　金：国家重点基础研究发展计划资助(2010CB834202);国家自然科学基金重点项目(10835011);国家自然科学基金面上项目(30770639);甘肃省重大科技专项项目(O702NKDA045;0801NKDA001);中央高校基本科研业务费专项资金资助项目(lzujbky-2009-96)~~

摘　　要：探讨了重离子束辐照后荷颊囊癌金黄地鼠血清中微量元素含量的变化趋势。采用0,4,6,8和12 Gy剂量的12C6+离子束对荷颊囊癌金黄地鼠辐照治疗后28 d取血,应用原子吸收光谱仪火焰法测定血清中Fe,Cu,Zn,Mg和Ca 5种微量元素的含量。金黄地鼠成瘤后,血清中微量Cu,Zn,Ca和Mg元素含量下降,均明显低于正常组(P<0.05);不同剂量的重离子束辐照后28 d,血清中5种微量元素在低剂量时均呈现继续下降趋势,在6或8 Gy时恢复到正常组水平,到12 Gy再呈降低的趋势,存在一定的剂量-反应关系。重离子束辐照影响荷颊囊癌金地鼠血清微量元素的含量,具有一定的临床意义。To study the trend of the changes of trace elements in serum of golden hamster with cheek pouch carcinoma after irradiation by heavy ion beam,the cheek pouch carcinoma of golden hamster was exposed to different doses of heavy ion beam,after 4 weeks,the contents of Cu,Zn,Fe,Mg and Ca in serum were detected by flame method of Atomic Absorption Spectrometer.The contents of Cu,Zn,Ca and Mg in experimental groups with cheek pouch carcinoma were significantly lower than that of the normal group（P0.05）.After irradiated by 0,4,6,8,12 Gy heavy ion beam,the 4 Gy group showed a tendency downward,when the irradiation dose reached 6 Gy,the contents of Fe,Zn were increased,and decreased at 12 Gy.While Cu,Ca and Mg content of 8 Gy group rose to the highest,and decreased at 12 Gy.All of the results showed a dose-reaction relationship（P0.05）.The irradiation of heavy ion beam maybe significantly affect the content of trace elements in serum of golden hamster with cheek pouch carcinoma.

关 键 词：重离子束 颊囊癌 微量元素 电离辐射 

分 类 号：Q691[生物学—生物物理学] R146[医药卫生—公共卫生与预防医学]