高频超声引导下A型肉毒杆菌毒素注射在甲状腺相关眼病限制性斜视中的应用  

Application of botulinum toxin A injection guided by high-frequency ultrasound in the treatment of restrictive strabismus in thyroid associated ophthalmopathy

作　　者：刘新华[1] 裴重刚[1] 邵毅[1] 缪超英[1] 黄小波[1] 

机构地区：[1]南昌大学第一附属医院眼科,中国江西省南昌市330006

出　　处：《国际眼科杂志》2011年第6期1070-1071,共2页International Eye Science

基　　金：中国江西省卫生厅科技计划项目~~

摘　　要：目的:探讨高频超声引导下注射A型肉毒杆菌毒素(botulinum toxin A,BTXA)治疗甲状腺相关眼病(thyroid associated ophthalmopathy,TAO)限制性斜视的临床效果。方法:选择32例TAO限制性斜视患者,在眼科高频超声引导下注射BTXA。观察注射前后的斜视度及复视的变化情况。结果:患者32例经重复注射2～4次BTXA后,其斜视度及复视情况有不同程度的减轻。总体显效率占47%,有效率占44%,无效率占9%。结论:高频超声引导下注射BTXA治疗TAO限制性斜视,定位准确,是一种有效缓解眼外肌痉挛和减轻复视症状及斜视度的方法。AIM：To observe the clinical effects of botulinum toxin A（BTXA） injection guided by high-frequency ultrasound in the treatment of restrictive strabismus in thyroid associated ophthalmopathy.METHODS： Thirty-two patients with restrictive strabismus in thyroid associated ophthalmopathy were recruited in clinical study.Under the guide of high-frequency B ultrasound diagnostic apparatus, BTXA was injected into the extra-ocular muscles.The changes of the degree of and strabismus diplopia were observed after therapy.RESULTS： In all eyes of 32 patients,the strabismus and diplopia were lessened in different degrees after repeated injection with botulinum toxin A in the affected extra-ocular muscles for 2 to 4 times. The total apparent rate was 47%,effective rate was 44%, ineffective rate was 9%.CONCLUSION： BTXA injection guided by high-frequency ultrasound technique is accurate positioning method in the treatment of restrictive strabismus in thyroid associated ophthalmopathy. It is an effective therapy to lighten the contraction of extra-ocular muscles remission of diplopia symptom and strabismus degree.

关 键 词：超声引导注射 肉毒杆菌毒素A 格雷夫斯病 斜视 

分 类 号：R581[医药卫生—内分泌] R771.3[医药卫生—内科学]