IFNα引起甲状腺功能亢进治疗的初探  

Investigation on the Treatment of Interferon-induced Hyperthyroidism

作　　者：张旭祥[1] 念馨[1] 蒋世钊[1] 

机构地区：[1]昆明医学院第一附属医院内分泌科,云南昆明650032

出　　处：《昆明医学院学报》2011年第4期71-73,共3页Journal of Kunming Medical College

摘　　要：目的探讨干扰素(IFNα)所致甲状腺功能亢进的治疗方案.方法入组病例共23例,随机分两组,抗甲亢药物组给予甲巯咪唑或丙硫氧嘧啶,病例13例,对症处理组给予普奈洛尔,病例10例.结果抗甲亢药物组与普奈洛尔对症处理组,在治疗3个月两组甲亢治疗缓解率无差异,6个月及12个月两组甲减发生率无差异.结论在IFNα所致甲亢的治疗方案中,抗甲亢药物治疗与普奈洛尔对症治疗效果无明显差异,停用IFNα是甲亢缓解的关键.Objective To investigate the treatment of interferon（IFN alpha）induced hyperthyroidism.Methods 23 patients with interferon-induced hyperthyroidism were randomly divided into two groups.13 patients in the treatment group were administered with anti-thyroid drugs of thiamazole or propyl thiouracil,10 patients in the control group were administered with propranolol.Results There was no significant difference in the remission rate of hyperthyroidism between the treatment group and control group 3 months after treatmen.There was no significance difference in the prevalence of hypothyroidism between the two groups 6 and 12 months after treatmen.Conclusion No significant difference can be found in the therapeutic effects on INF-alpha induced hyperthyroidism between anti-thyroid and propranolol therapy,cessation of INF-alpha plays a key role in the remission of hyperthyroidism.

关 键 词：干扰素 甲状腺功能亢进 治疗 

分 类 号：R581.1[医药卫生—内分泌]