早期续贯性TPN+EN治疗对重型颅脑损伤患者营养状态、免疫功能的影响  

Effect of early unremitting treatment with total parenteral nutrition and enteral nutrition on nutritional status and immune function in patients with severe traumatic brain injury

作　　者：黄志纯[1] 田新华[1] 陈锷[1] 张峰林[1] 邓志鸿[1] 李泉清[1] 陈陆馗[1] 孙瑾[1] 康俊龙[1] 

机构地区：[1]福建医科大学教学医院厦门中山医院神经外科,福建厦门361004

出　　处：《医学信息（中旬刊）》2011年第6期2238-2240,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的:探讨早期续贯性TPN+EN治疗对早期重型颅脑损伤患者免疫功能和营养代谢的影响。方法:采用前瞻性对比研究方法,将60例病人随机分为试验组和对照组,每组各30例,试验组给予早期续贯性TPN+EN治疗;对照组给予常规EN治疗,共14d。观察两组病人营养支持期间IgA、IgG、IgM、CD4+、CD8+、血清ALB、TF、Hb、氮平衡、并发症等。结果:试验组病人IgA、IgG、CD4+和CD4+/CD8+比值、TF均高于对照组(P<0.05),实验组患者并发症少于对照组。结论:早期续贯性TPN+EN治疗能减少重型颅脑损伤并发症,改善患者免疫功能、营养状态和预后。Objective：To investigate early unremitting treatment with total parenteral nutrition and enteral nutrition on nutritional status and immune function in patients with severe traumatic brain injury.Methods：A prospective control study was carried out.60 cases of severe brain injury were randomly divided into experimental group and control group.The experimental group was treated with total parenteral nutrition and enteral nutrition for 14 days.The control group was treated with peripheral parenteral nutrition 14 days.Serum albumin,transferin,hemoglobin,nitrogen balance,complication,IgA,IgG,IgM,CD4（%） and CD8（%） were detected before and after nutrition support.Results：Compared with control group,IgA,IgG,CD4（%）,CD4/CD8,transferin in experimental group increased significantly （P〈0.05）.The complications of experimental group were less than control group.Conclusions：Unremitting treatment with early enteral and parenteral nutrition can promote recovery of patients nutritional status,immune function and prediction.

关 键 词：重型颅脑损伤 肠外营养 肠内营养 免疫功能 

分 类 号：R651.15[医药卫生—外科学]