不明原因肝病患者中隐匿性HBV感染的研究  

The study of occult HBV infection in the unknown etiology patients

作　　者：马源[1] 张玲荣[1] 王博[1] 景孟玲[1] 于佳妮[1] 朱新宇[1] 

机构地区：[1]山西医科大学第一临床医学院传染病科,太原030001

出　　处：《中国医疗前沿》2011年第9期5-6,共2页China Healthcare Innovation

基　　金：太原市科技厅经费资助项目(编号:0903059)

摘　　要：目的了解不明原因肝病患者中隐匿性HBV感染的情况及与临床的关系。方法采用酶联免疫吸附实验(ELISA)检测89例不明原因肝病患者血清乙肝病毒标志物(HBVM),应用巢式PCR方法检测血清中HBVDNA。结果 89例不明原因肝病患者中,HBVDNA阳性18例。其中,HBVM全阴性3例,抗HBc阳性14例,抗HBe+抗HBc阳性1例。隐匿性HBV感染者中,慢性肝炎5例,占10.41%(5/48);肝硬化者12例,占38.9%(12/37);肝癌1例,占25%(1/4)。结论不明原因肝病患者中隐匿性HBV感染率为20.22%,并与肝硬化关系密切。Objective To investigate the circumstances and the relationship with clinical of occult HBV infection in unknown etiology patients. Methods The serum HBV marker of 89 cases of the unknown patients were detected by ELISA, serum HBVDNA were detected by n-PeR. Results In 89 patients of unknown etiology, 18 cases were positive with HBVDNA. Among them, 3 cases were negative with whole HBVM, 14 cases were positive with anti- HBc, 1 case were positive with anti-HBe＋anti-HBc. In the patients with occult HBV infection, 5 cases were chronic hepatitis, 10.41%（5/48）~ 12 cases were liver cirrohosis, 38.9%（12/37）, 1 case were hepatocellular carcinoma, 25%（1/4）. Conclusion The rates of occult HBV infection in unknown etiology patients were 20.22%, and may induce liver cirrohosis.

关 键 词：隐匿性感染 血清学标志物 乙肝 HBVDNA 

分 类 号：R512.6[医药卫生—内科学] R575[医药卫生—临床医学]