骨痛膏局部外敷对膝关节炎家兔的骨内压及血液流变学的影响  

Impaction of Hemorrheology and Intraosseous Hypertension of the Rabbits with Knee OA Treated with Gutong Herb Paste

作　　者：曾俊华[1] 张方建[1] 白书臣[1] 李浩[1] 戴炎炎 

机构地区：[1]湖北省中医院,武汉430061 [2]武汉市中医院

出　　处：《中国中医骨伤科杂志》2011年第6期9-11,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

摘　　要：目的：观察中药制剂骨痛膏局部外敷对膝关节炎家兔的骨内压及血液流变学的影响及作用,为中药临床治疗骨性关节炎（OA）提供实验依据。方法：日本大耳白兔,32只,体重2-2.5kg左右,随机分为正常组、造模组、骨痛膏组（用药组）、天和骨通膏组（对照组）。每组8只,除正常组外,均在无菌条件下,行右侧股静脉结扎,建立兔骨性关节炎模型.正常组与造模组不予处理。8周后,骨痛膏组用骨痛膏行右膝关节外敷,3天1次,共3周。天和骨通膏组用天和骨通膏行右膝关节外敷,3天1次。共3周。后用BL-410生物机能系统测量兔双膝关节骨内压,然后取骨髓血测量血液流变学,骨内压测量结果采用配对资料均数的t检验进行分析,骨髓血血液流变学检测结果采用q检验进行分析。结果：造模组兔右膝关节发生了类似于临床早期OA的病理改变：骨内压较正常组明显升高（P〈0.01）,骨髓血血液流变学状态较正常组有明显改变（P〈0.01）。经过3周的治疗,用药组的骨内压和血液流变学等各项指标均趋于正常（P〉0.05）,而对照组的骨内压和血液流变学等各项指标与正常组相比差异有统计学意义（P〈0.01）。结论：骨痛膏外敷能有效降低膝关节家兔骨内高压,明显改善骨髓血血液流变学状态,并可使其恢复至正常水平,从而起到延缓关节软骨的退变,有利于软骨修复的作用。Objective：To observe the impaction of hemorrheology and intraosseous hypertension of the rabbits with knee OA treated with Gutong Herb Paste,provide experimental bases for the clinical application of Gutong Herb Paste.Methods：Japanese big-eared rabbits which were from 2 kg to 2.5 kg,were randomly divided into 4 groups：the normal group,the model group,the Gutong Herb Paste group（abbreviated give drug group the following）,and the Tianhegutong Herb Paste group（abbreviated contrast group the following）,8 rabbits each group.The models of knee OA were made by ligating the right femoral vein of rabbits,except all the rabbits in the normal group,under the condition of sterility.All the rabbits in the Gutong Herb Paste group and the Tianhegutong Herb Paste group were treated with Gutong Herb Paste and Tianhegutong Herb Paste,once for 3 days,3 weeks together,in the 8th week after modeling.Knee intraosseous hypertension was measured with the BL-410 biology enginery system,and the hemorrheology were also measured at the end of experiment.The date of intraosseous hypertension were analyzed by T-test,the date of marrow blood hemorrheology were analyzed by q-test.Result：Pathological changes of knee OA were found in rabbits in the model group.The intraosseous hypertension of rabbits in the model group was higher than that in the normal group（P0.01）,the changes of hemorrheology of marrow blood in the model group were greater than that in the normal group（P0.01）.There was statistical difference in the hemorrheology and intraosseous hypertension between the Gutong Herb Paste group and the Tianhegutong Herb Paste group,but the hemorrheology and intraosseous hypertension returned to balance（P0.05）,after 3 weeks treatment.Conclusion：Gutong Herb Paste can delay the degeneration of articular cartilage and repair cartilage by reducing the intraosseous hypertension within the knee joint in rabbits,and improving the status of hemorrheology.

关 键 词：骨关节炎 外敷 骨内压 血液流变学 

分 类 号：R285.5[医药卫生—中药学]