靶控输注依托咪酯与舒芬太尼联合用于无痛流产术的研究  

The Anesthetic Elect of Target - Controlled Sufentanil in Painless Artificial

作　　者：邵晓青[1] 王俊梅[1] 许强[1] 

机构地区：[1]山东省潍坊市妇幼保健院,261011

出　　处：《健康必读（下）》2011年第6期47-48,共2页

摘　　要：目的：探讨不同血浆靶浓度依托咪酯靶控输注（TCI）联合一定剂量舒芬太尼用于无痛人工流产手术的合理配伍。方法：80例早孕患者，随机分为4组。Ⅰ组单纯用依托咪酯，血浆靶浓度设定为0．6mg／l，Ⅱ、Ⅲ、Ⅳ组在输注依托咪酯前2分钟先静脉注射0．12ug／kg舒芬太尼。注药时间30秒，Ⅱ、Ⅲ、Ⅳ组依托咪酯血浆靶浓度分别设定为0．3mg／l、0．4mg／1、0．5mg／l。待患者睫毛反射消失，双频脑电图值（BIS）降至40后开始手术，吸宫结束时停依托咪酯。监测患者的收缩压（SBP）、舒张压（DBP）、脉膊氧饱和度（SPO2）、HR和BIS值，并记录诱导时间、手术时间、唤醒时间和定向力恢复时间、依托咪酯的总用量、患者体动及术后宫缩痛等情况。结果：与对照组相比，各舒芬太尼组的依托咪酯用量均降低，其唤醒时间、定向力恢复时间较短，血流动力学亦较平稳，术后宫缩痛明显减轻。结论：采用0．4mg／l依托咪酯TCI与0.12ug／kg舒芬太尼配伍用药，术后苏醒迅速。为最适依托咪酯TCI浓度。Objective ：To explore the reasonable target plasma concentration of etomidate combined with sufentanil in anesthesia of painless artificial abortion. Methods：Eighty patients were randomly divided into four groups：group Ⅰ Only accepted etomidate at plasma concentration of 0.6mg/l. Group Ⅱ, Ⅲ, and Ⅳ accepted injection of sufentanil（0.12ug/kg） combined with etomidate of plasma eoncentmtion at 0.3mg/1,0.4mg/l, and 0.5mg/l respectively. Patients＇ SBP,blood pressure, SpO2, HR, and BIS were monitored. Induction time, operation time , awake time, orientation reoovery time , overall consumption of etomidate, patients＇ bodymotion, and postoperative uterine contraction pain were observed . Results： Compared with group Ⅰ, groups Ⅱ, Ⅲ , and Ⅳ bad less overall consumption of etomidate,shorter awake time and orientation recovery time ,with more stable hemodynamics and less postoperative uterine contraction pain. Conclusions ：Target plasma etomidate concentration of 0.4mg/l combined with sufentanil（0.12ug/kg ） gives more eficient anesthesia and better recovery in painless artificial abortion.

关 键 词：靶控输注 无痛人工流产 依托咪酯 舒芬太尼 

分 类 号：R614[医药卫生—麻醉学]