水动力学色谱及其在微粒制剂评价中的应用进展  

Progress of the hydrokinetic chromatography and its application in the characterization of particulate drug delivery systems

作　　者：刘薇[1,2] 李海燕[2] 郭桢[2,3] 张继稳[2] 孙立新[1] 

机构地区：[1]沈阳药科大学 [2]中国科学院上海药物研究所 [3]浙江中医药大学

出　　处：《药学学报》2011年第6期631-636,共6页Acta Pharmaceutica Sinica

摘　　要：本文在介绍流体动力学色谱中应用最广泛的水动力色谱基本原理、装置和分析方法的基础上,综述了水动力色谱在微粒制剂粒径测定及其分布估算方面的应用。该方法在快速测定纳米、微米尺度颗粒的粒径方面具有经济、便捷和无损伤等独特的优势,在微粒制剂粒径分布特征检测上具有良好的应用前景。In the present paper,the basic principles,the device and the analytical method of the hydrodynamic chromatography（HDC） were summarized,which is most widely used in hydrokinetic chromatography.The application of the hydrodynamic chromatography in the determination of the particle size and size distribution of the particulate drug delivery system was also reviewed.The method can determine the particle size of nano-and micron-scale particulate drug delivery systems rapidly.And this method also has the advantages of economic,convenient and no damage to the samples.In summary,there will be a good prospect for the application of HDC in the determination of particle size distribution features of particulate drug delivery systems.

关 键 词：水动力色谱 微粒制剂 粒径 粒径分布 

分 类 号：R917[医药卫生—药物分析学]